Gonorrhea – Cannabis THC : CBD Ratios

Gonorrhea Research Dashboard

2

Primary Studies

2

Related Studies

4

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 4 studies associated with Gonorrhea.

Here is a small sampling of Gonorrhea studies by title:


Components of the Gonorrhea Research Dashboard

  • Dosing information available for Gonorrhea
  • Chemotype guidance for treating Gonorrhea with cannabis
  • Synopsis of cannabis research for Gonorrhea
  • Individual study details for Gonorrhea

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Overview - Gonorrhea

Description of Gonorrhea

Gonorrhea is a curable disease caused by gonococcus or Neisseria gonorrhea bacteria. It is usually sexually transmitted, though an infected mother can transmit the disease to an infant during birth. Gonorrhea symptoms in infants are mostly limited to infections of the eyes. In adults, gonorrhea affects the mucous membranes of the genitals, reproductive organs, the anus, or the throat. It is estimated that about 1 in 10 infected males and 5 in 10 infected females show no or very mild physical symptoms of the disease. Early symptoms of the disease usually occur within the first week after exposure but may present up to 30 days after infection. Both sexes may experience rectal or throat infections of gonorrhea. While rectal infection may produce less severe symptoms, rectal discharge, anal itching, and pain during bowel movements may be present. Untreated gonorrhea can cause infertility in men as well as women. Gonorrhea may soon become a “superbug” infection, resistant to all known antibiotics. As a consequence, there is global interest in the search for new and effective remedies for gonorrhea.

Disease Classification

Condition: Gonorrhea
Disease Family:
Organ System: Immune System
ICD-10 Chapter: Certain infectious and parasitic diseases
ICD-10 Code: A54.9

Gonorrhea Symptoms:

Burning, painful, and/or itching sensation when urinating, unusual vaginal or penile discharge or pus (white, yellowish, sometimes with an odor), spotting or bleeding between menstrual cycles, vaginal bleed between periods, may progress to pelvic inflammatory disease (in females) and the inflammation of the epididymis and testicles in males (with associated pain and swelling of the groin and scrotum), abscesses along the affected mucous membranes, damage to the reproductive organs, increased risk for ectopic pregnancies and infertility, abdominal pain, pelvic pain, if left untreated symptoms may spread to the heart valves or joints, in cases of oral infections symptoms may include sore throat and/or swollen lymph nodes around the neck, rectal infections present commonly with rectal itching or pain, and discharge.

Also known as:

The clap, Venus's curse, Cupid's itch, sexually transmitted disease (STD), venereal disease (VD), gonorrhoea

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.