Gingivitis and Periodontal Disease – Cannabis THC : CBD Ratios

Gingivitis and Periodontal Disease Research Dashboard

7

Primary Studies

2

Related Studies

9

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

3

Animal studies

0

Laboratory studies

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CannaKeys has 9 studies associated with Gingivitis and Periodontal Disease.

Here is a small sampling of Gingivitis and Periodontal Disease studies by title:


Components of the Gingivitis and Periodontal Disease Research Dashboard

  • Dosing information available for Gingivitis and Periodontal Disease
  • Chemotype guidance for treating Gingivitis and Periodontal Disease with cannabis
  • Synopsis of cannabis research for Gingivitis and Periodontal Disease
  • Individual study details for Gingivitis and Periodontal Disease

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Overview - Gingivitis and Periodontal Disease

Description of Gingivitis and Periodontal Disease

Peridontal disease aka gum disease is a generally inflammatory condition that affects the oral tissues surrounding the teeth (the periodontium). Contributing factors include an unhealthy oral microbiome or biofilm (including fungal infections), smoking, poor oral hygene, poor nurition and a number of contributing diseases such as alcohol use disorder or diabetes for example. Early expressions of peridontal disease may express as gingivitis (inflammation of the gum) while disease progression can lead to a more severe form may involve recession of gums and loss of teeths. Peridontitis may also be a contributing factor in a number of other more serious conditions such as abcess formation, heart attack, or cognitive impairment for example. Orthodox treatment options include improving dental hygene, deep cleaning, the use of an oxidant such as hydrogen peroxide or ozone, the use of a laser, addressing potential underlying conditions, and surgery.

Disease Classification

Condition: Periodontal Disease
Disease Family:
Organ System: Digestive System
ICD-10 Chapter: Gingivitis and Periodontal Diseases
ICD-10 Code: K05

Gingivitis and Periodontal Disease Symptoms:

Redness, swelling, pain, bleeding, halitosis, recession of supportive tissues, loose teeth, loss of teeth (dental decay)

Also known as:

Gum Disease, Gingivitis, Periodontitis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.