Geriatric Conditions – Cannabis THC : CBD Ratios

Geriatric Conditions Research Dashboard

16

Primary Studies

5

Related Studies

21

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

9

Meta-analyses/Reviews

5

Animal studies

1

Laboratory studies

What am I missing as a non-subscriber?

To see a full dashboard with study details and filtering, go to our DEMO page.

As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 21 studies associated with Geriatric Conditions.

Here is a small sampling of Geriatric Conditions studies by title:


Components of the Geriatric Conditions Research Dashboard

  • Dosing information available for Geriatric Conditions
  • Chemotype guidance for treating Geriatric Conditions with cannabis
  • Synopsis of cannabis research for Geriatric Conditions
  • Individual study details for Geriatric Conditions

Ready to become a subscriber? Go to our PRICING page.

Select New Condition

Search By Keyword

Filter Condition

Members can filter by the following criteria:

  • Study Type
  • Chemotype
  • Cannabinoids & Endocannabinoids
  • Terpenes
  • Receptors
  • Ligands
  • Study Result
  • Year of Publication

Overview - Geriatric Conditions

Description of Geriatric Conditions

Gerontology is the study of aging. Geriatric medicine focuses on condition primarily affecting seniors. Scientists do not yet have a thorough understanding of the physiological mechanism of aging. Various theories have been proposed to explain the loss of cellular integrity that we recognize as aging (wrinkles, age spots, or decline in physical and mental function). Such theories largely focus on the cumulative effects of exposure to radiation, toxins, or pathogens contributing to mutation in cellular DNA over time. Specifically, the following are believed to be causal agents in the process of aging: accumulation of toxins, the long-term effect of ionizing radiation, changes in hormone profiles, damage from exposure to free radicals (oxidative stressors), exposure to parasites, fungi, bacteria, viruses, or other pathogens, shortening of the end strings of DNA (called telomeres, which occurs with each cell division and in the presence of environmental toxins), and the accumulation of senescent (older) cells.

Disease Classification

Condition: Aging
Disease Family: Aging
Organ System: Muscular System, Nervous System, Skeletal System
ICD-10 Chapter: N/A
ICD-10 Code: N/A

Geriatric Conditions Symptoms:

Physical (e.g. epigenetic changes, mutation, telomere shortening, wrinkles, age-spots, greying hair, loss of body mass, loss of visual focus, male/female menopause). Mental/emotional (e.g. loss of memory or other cognitive impairments)

Also known as:

Aging-related conditions, Aging, Frailty, Old Age,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
Top

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.