Fibromyalgia – Cannabis THC : CBD Ratios

Fibromyalgia Research Dashboard

12

Primary Studies

7

Related Studies

19

Total Studies

Clinical Studies

4

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 19 studies associated with Fibromyalgia.

Here is a small sampling of Fibromyalgia studies by title:


Components of the Fibromyalgia Research Dashboard

  • Dosing information available for Fibromyalgia
  • Chemotype guidance for treating Fibromyalgia with cannabis
  • Synopsis of cannabis research for Fibromyalgia
  • Individual study details for Fibromyalgia

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Overview - Fibromyalgia

Description of Fibromyalgia

Fibromyalgia, an illness characterized by chronic pain combined with some form of psychiatric diagnosis, still lacks an observable underlying pathology. The disease picture of fibromyalgia usually includes widespread chronic pains in muscles and connective tissue, joint stiffness, general weakness, exhaustion, depression, anxiety, and insomnia. Nearly 2 percent of the general population in the United States suffers from fibromyalgia, the majority of them being middle-aged females. No specific test exists to determine an exact diagnosis. Symptoms are often similar to those of rheumatism, osteoporosis, or arthritis. Physicians try to diagnose by process of elimination. Diagnostic criteria established by the American College of Rheumatology include the following: a history of diffused and chronic pains for more than three months and present in all four quadrants of the body, and the presence of pain in at least 11 of 18 specific trigger points.

Disease Classification

Condition: Fibromyalgia
Disease Family: Neurological Disease
Organ System: Muscular System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M79.7

Fibromyalgia Symptoms:

Chronic and widely spread pain (dull), malaise, mild cognitive difficulty (e.g. mental fog, difficulty concentrating), sleep disturbances, allodynia (normal sensation are painful), weakness

Also known as:

FMA, Fibromyositis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.