Fever – Cannabis THC : CBD Ratios

Fever Research Dashboard

21

Primary Studies

2

Related Studies

23

Total Studies

Clinical Studies

1

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

17

Animal studies

0

Laboratory studies

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CannaKeys has 23 studies associated with Fever.

Here is a small sampling of Fever studies by title:


Components of the Fever Research Dashboard

  • Dosing information available for Fever
  • Chemotype guidance for treating Fever with cannabis
  • Synopsis of cannabis research for Fever
  • Individual study details for Fever

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Overview - Fever

Description of Fever

When it comes to fever there are a couple of considerations that you might find surprising or instructive. First, there is a growing body of evidence that posits that fever is one of the body’s primary therapeutic responses to infections such as a respiratory virus for example. In that context a fever (a rise in temperature of 1- 4°C above baseline) is associated with the resolution of viral infections and increased survival rates in humans. A fever stimulates both our adaptive and innate immune responses and as such contributes to the destruction of microbial invader while simultaneously recruiting and increasing the production of relevant immune cells needed to restore health and well-being. Instead of being an enemy, fever can actually be considered an ally as long as it remains relatively low and lasts for only a relatively short time (~three days). As such, our reflex to instantly treat fever with antipyretics may actually do more harm than good. However, if fever creeps higher or lasts too long (especially in children) especially in the presence of fever-induced symptoms (e.g. febrile seizures) steps to reduce it become necessary. Secondly, taking the results of a systematic literature review of what is considered a normal body temperature is not a fixed number that all people equally but lies on a spectrum that can vary (+/- 1.5°C or 2.7°F) between individuals including differences in genders.

Disease Classification

Condition: Fever
Disease Family: Infectious Disease (Microbial) also some non-infectious causes
Organ System: Immune System
ICD-10 Chapter: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
ICD-10 Code: R50

Fever Symptoms:

A rise in temperature of 1- 4°C above baseline.

Also known as:

Drug-induced fever, Post-procedural fever, Post vaccination fever

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.