Endometriosis and Adenomyosis – Cannabis THC : CBD Ratios

Endometriosis and Adenomyosis Research Dashboard

8

Primary Studies

0

Related Studies

8

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

2

Animal studies

1

Laboratory studies

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CannaKeys has 8 studies associated with Endometriosis and Adenomyosis.

Here is a small sampling of Endometriosis and Adenomyosis studies by title:


Components of the Endometriosis and Adenomyosis Research Dashboard

  • Dosing information available for Endometriosis and Adenomyosis
  • Chemotype guidance for treating Endometriosis and Adenomyosis with cannabis
  • Synopsis of cannabis research for Endometriosis and Adenomyosis
  • Individual study details for Endometriosis and Adenomyosis

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Overview - Endometriosis and Adenomyosis

Description of Endometriosis and Adenomyosis

Endometriosis is a proliferation of interior cells outside the uterus. Displaced cells continue to respond to hormonal changes and behave as they would inside the uterus; however, without an easy exit they remain, causing growth and adhesions. This can be extremely painful. Growths and adhesions may spread throughout the pelvic cavity and form attachments on the ovaries, bowels, or any other surrounding tissue. The exact causes of endometriosis remain unclear. Doctors hypothesize that a causes of endometriosis may lies with exposure to environmental toxins (i.e. dioxin) or in menstrual blood containing endometrial cells that returns via the fallopian tubes to the pelvic cavity. This process is called retrograde menstruation. Orthodox treatments include pain management, hormonal supplementation, and surgery. In contrast, adenomyosis occurs when the lining grows into the muscle of the uterus itself causing abnormal thickness.

Disease Classification

Condition: Endometriosis
Disease Family: Gynecological Condition
Organ System: Endocrine System
ICD-10 Chapter: Diseases of the Genitourinary System
ICD-10 Code: N80

Endometriosis and Adenomyosis Symptoms:

Chronic lower abdominal pain, painful intercourse, dysmenorrhea (e.g. spotting, heavy bleeding, cramps), pain when urinating, pain with bowel movement, increased pain with movement or pressure, infertility

Also known as:

ENDO

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.