Colon Cancer – Cannabis THC : CBD Ratios

Colon Cancer Research Dashboard

19

Primary Studies

7

Related Studies

26

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

4

Animal studies

14

Laboratory studies

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CannaKeys has 26 studies associated with Colon Cancer.

Here is a small sampling of Colon Cancer studies by title:


Components of the Colon Cancer Research Dashboard

  • Dosing information available for Colon Cancer
  • Chemotype guidance for treating Colon Cancer with cannabis
  • Synopsis of cannabis research for Colon Cancer
  • Individual study details for Colon Cancer

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Overview - Colon Cancer

Description of Colon Cancer

Colon cancer develops in the epithelial cells (lining), which may be found as high up as the junction between the large and small intestine or anywhere following its pathway to the anus. Hypothesized causes include cellular mutations by inheritance or dietary exposure to carcinogens. Other known aspects that increase the risk of developing colon cancer are the presence of colon polyps, irritable bowel syndrome, and ulcerative colitis. Additional risk factors include: smoking tobacco, use of alcohol, aged 50 or over, male gender, obesity, a sedentary lifestyle, the presence of other environmental carcinogens, African American heritage, and receiving radiation therapy for cancer. Within allopathic medicine, colon cancer is diagnosed by colonoscopies, biopsies, or using imaging technology utilizing ionizing radiation, such as contrast x-rays and CT scans. Treatments include chemotherapy, radiation, or surgery.

Disease Classification

Condition: Colon Cancer
Disease Family: Cancer
Organ System: Digestive System
ICD-10 Chapter: Neoplasms
ICD-10 Code: C18

Colon Cancer Symptoms:

Chronic changes in your bowel movement (e.g. constipation, diarrhea, pencil/skinny bowel movements), persistent abdominal discomfort or pain, rectal bleed, feeling of incomplete void, weakness, unintentioned weightloss, nausea or vomiting, lack of appetite,

Also known as:

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.