Cocaine Dependence – Cannabis THC : CBD Ratios

Cocaine Dependence Research Dashboard

9

Primary Studies

5

Related Studies

14

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

3

Animal studies

0

Laboratory studies

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CannaKeys has 14 studies associated with Cocaine Dependence.

Here is a small sampling of Cocaine Dependence studies by title:


Components of the Cocaine Dependence Research Dashboard

  • Dosing information available for Cocaine Dependence
  • Chemotype guidance for treating Cocaine Dependence with cannabis
  • Synopsis of cannabis research for Cocaine Dependence
  • Individual study details for Cocaine Dependence

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Overview - Cocaine Dependence

Description of Cocaine Dependence

Cocaine is made from the leaves of the coca plant native to South America. While it has a role to play in the doctor's tool box (e.g. local anesthesia for sutures for example) recreational use is illegal. People like to use the substance because it makes experience an emotional reality that is happy, energetic, productive, confident. On the other end of cocaine's effect spectrum it can produce paranoia and erratic, violent behavior. Cocaine use can also produce physical and mental-emotional addiction with significant adverse effects (e.g. heart attacks) and potentially fatal outcomes.

Disease Classification

Condition: Cocaine Dependence
Disease Family: Addiction
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F14.2

Cocaine Dependence Symptoms:

Tachycardia, hypertension, paranoia, restlessness, aggression, depression, hallucinations, craving for cocaine, fatique, insomnia

Also known as:

Cocaine Addiction

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.