Cerebral Palsy and Related Syndromes – Cannabis THC : CBD Ratios

Cerebral Palsy and Related Syndromes Research Dashboard

6

Primary Studies

0

Related Studies

6

Total Studies

Clinical Studies

1

Double-blind human trials

3

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 6 studies associated with Cerebral Palsy and Related Syndromes.

Here is a small sampling of Cerebral Palsy and Related Syndromes studies by title:


Components of the Cerebral Palsy and Related Syndromes Research Dashboard

  • Dosing information available for Cerebral Palsy and Related Syndromes
  • Chemotype guidance for treating Cerebral Palsy and Related Syndromes with cannabis
  • Synopsis of cannabis research for Cerebral Palsy and Related Syndromes
  • Individual study details for Cerebral Palsy and Related Syndromes

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Overview - Cerebral Palsy and Related Syndromes

Description of Cerebral Palsy and Related Syndromes

Taken from the Greek word 'spasmos' meaning convulsion. Usually it is used to describe a sudden onset involuntary contraction of a muscle or a group of muscles or involving the whole body for example. Pediatric spasticity can be acute or chronic. A number of different movement or seizure disorders can to produce pediatric spasticity (e.g. cerebral palsy, CNS trauma). Chronic spasticity can be a challenge to basic movement, posture and balance. Depending on underlying condition orthodox treatment options are usually limited to pharmaceutical drugs, orthotic support (e.g. brace, splint), and surgery.

Disease Classification

Condition: Cerebral Palsy
Disease Family: Neurological Disease
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G80-G83

Cerebral Palsy and Related Syndromes Symptoms:

Muscular pain (chronic), stiffness, fixed contraction (cramping), other chronic types of pains, partial or generalized weakness, lack of balance, numbness, impaired cognitive functions (e.g. memory loss), loss of vision, shortness of breath

Also known as:

Spasicity, Hemiplegia, Tetraplegia, Paraplegia,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.