Bone Fractures – Cannabis THC : CBD Ratios

Bone Fractures Research Dashboard

6

Primary Studies

0

Related Studies

6

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

2

Animal studies

0

Laboratory studies

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CannaKeys has 6 studies associated with Bone Fractures.

Here is a small sampling of Bone Fractures studies by title:


Components of the Bone Fractures Research Dashboard

  • Dosing information available for Bone Fractures
  • Chemotype guidance for treating Bone Fractures with cannabis
  • Synopsis of cannabis research for Bone Fractures
  • Individual study details for Bone Fractures

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Overview - Bone Fractures

Description of Bone Fractures

Bone fractures are generally classified as closed or open (compound) fractures. The latter being fractures where bone segments are actually protruding through the surrounding tissue. Closed fractures can range in severity from mild hairline fractures, to partial fractures, or complete fractures but where the surrounding tissue is still intact. A compound fracture is easy to spot. Bone is sticking out through the skin. There is severe pain, and localized swelling and bleeding is clearly present. Complete but closed fracture presents with dangling limbs, severe pain, and swelling, but without external blood loss. A closed but incomplete or partial fracture may only present with pain and swelling similar to a sprain or strain but most likely with increased intensities. In the orthodox medical paradigm, a minor fracture such as a hairline fracture is merely immobilized and treated with pharmaceutical medication to reduce inflammation and pain. A completely fractured bone is set (realigned) manually, or surgically if necessary, and then placed into a semi-permanent cast for a period of 3 to 10 weeks (depending on location of fracture and age of patient), the idea being that the fracture must remain undisturbed to heal.

Disease Classification

Condition: Bone Fractures
Disease Family: Trauma
Organ System: Integumentary System, Muscular System, Skeletal System
ICD-10 Chapter: N/A
ICD-10 Code: N/A

Bone Fractures Symptoms:

Pain (acute, can be severe), deformity of effected body part, loss of skeletal integrity at affected part, swelling, loss or reduction or sensation in distal aspect, inability to bear weight, protruding bone, shortening of extremities, muscle spasms, bleeding, hematoma

Also known as:

FX, Broken bones,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.