Bone Cancer – Cannabis THC : CBD Ratios

Bone Cancer Research Dashboard

6

Primary Studies

0

Related Studies

6

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

3

Animal studies

1

Laboratory studies

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CannaKeys has 6 studies associated with Bone Cancer.

Here is a small sampling of Bone Cancer studies by title:


Components of the Bone Cancer Research Dashboard

  • Dosing information available for Bone Cancer
  • Chemotype guidance for treating Bone Cancer with cannabis
  • Synopsis of cannabis research for Bone Cancer
  • Individual study details for Bone Cancer

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Overview - Bone Cancer

Description of Bone Cancer

This type of cancer is relatively rare. The cancer cells proliferate within the bones' tissues, eventually forming tumors. Orthodox medicine differentiates between bone cancers that originate in the bone, calling these primary, and secondary cancers that develop in the bone tissue after spreading from another place (metastasizing). Tumors may develop slowly over time, making their presence known through gradually increasing discomfort, visible deformities, and pain. The tumor often exerts pressure from the inside, which, combined with loss of bone density and strength, may produce fractures of the bones or make them much more vulnerable to breakage. Orthodox medical treatments are limited to chemotherapy, radiation, and surgeries (amputations).

Disease Classification

Condition: Bone Cancer
Disease Family: Cancer
Organ System: Skeletal System
ICD-10 Chapter: Neoplasms
ICD-10 Code: C40

Bone Cancer Symptoms:

Bone pain, fatigue, anemia, loss of bone integrity, increased vulnerability to fractures

Also known as:

Neoplasm of the Bone

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.