Anxiety and Panic Disorders – Cannabis THC : CBD Ratios

Anxiety and Panic Disorders Research Dashboard

72

Primary Studies

69

Related Studies

141

Total Studies

Clinical Studies

13

Double-blind human trials

5

Clinical human trials

Pre-Clinical Studies

26

Meta-analyses/Reviews

27

Animal studies

1

Laboratory studies

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CannaKeys has 141 studies associated with Anxiety and Panic Disorders.

Here is a small sampling of Anxiety and Panic Disorders studies by title:


Components of the Anxiety and Panic Disorders Research Dashboard

  • Dosing information available for Anxiety and Panic Disorders
  • Chemotype guidance for treating Anxiety and Panic Disorders with cannabis
  • Synopsis of cannabis research for Anxiety and Panic Disorders
  • Individual study details for Anxiety and Panic Disorders

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Overview - Anxiety and Panic Disorders

Description of Anxiety and Panic Disorders

Generally speaking, anxiety is a normal reaction to the subjective experience of stress, such as in performance anxiety. It can occur when anticipation of future events is associated in one's mind with thoughts and feelings not rooted in the present moment. While anxieties can be considered a normal part of life, chronic or constant anxiety can be debilitating to one's quality of life. In fact, such interference can produce very real physiological changes in the short and long term. It is estimated that almost two out of ten people in the U.S. suffer from some kind of anxiety disorder. Western medicine considers anxiety disorders mood disorders and defines five basic types: generalized anxiety disorder (GAD), obsessive- compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and social anxiety disorder (social phobias).

Disease Classification

Condition: Anxiety
Disease Family: Mental Disorders
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F41

Anxiety and Panic Disorders Symptoms:

Worry, stress, fear, sleep disturmences, ruminating, panic attacks, increase in heart rate, rapid or shallow respiration (hyperventilation), dry mouth, muscular tension, tingling in lips, nose, and the digits of hands and feet, inability to relax, sense of impending doom, inability to focus on anything other than the current worry scenario

Also known as:

Panic Attacks, Generalized Anxiety Disorder

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.