Adverse Effects from MDMA/Ecstacy Research Dashboard
Double-blind human trials
Clinical human trials
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CannaKeys has 36 studies associated with Adverse Effects from MDMA/Ecstacy.
Here is a small sampling of Adverse Effects from MDMA/Ecstacy studies by title:
- Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2)
- Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder
- Drugs of Misuse: Focus on Vascular Dysfunction
- Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders
- Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens
Components of the Adverse Effects from MDMA/Ecstacy Research Dashboard
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- Chemotype guidance for treating Adverse Effects from MDMA/Ecstacy with cannabis
- Synopsis of cannabis research for Adverse Effects from MDMA/Ecstacy
- Individual study details for Adverse Effects from MDMA/Ecstacy
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Overview - Adverse Effects from MDMA/Ecstacy
Description of Adverse Effects from MDMA/Ecstacy
Ingestion of MDMA (Ecstacy) can produce sensory arousal, hyperthermia, oxidative stress and serotonergic neurotoxicity.
MDMA Adverse Effects
Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T43.64
Adverse Effects from MDMA/Ecstacy Symptoms:
Adverse effect while on MDMA (e.g. sensitivity to cold, jaw clenching, dry mouth/thirst, dizzyness, weakness). After the effects of MDMA wear off symptoms may include depression, irritability, anger.
Also known as:
Poisoning by ecstacy
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.