Tetrahydrocannabinolic Acid (THC-a) Cannabinoid Research

Tetrahydrocannabinolic Acid (THC-a) Research Dashboard


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CannaKeys has 56 studies associated with Tetrahydrocannabinolic Acid (THC-a).

Here is a small sampling of Tetrahydrocannabinolic Acid (THC-a) studies by title:

Components of the Tetrahydrocannabinolic Acid (THC-a) Research Dashboard

  • Top medical conditions associated with Tetrahydrocannabinolic Acid (THC-a)
  • Proven effects in clinical trials for Tetrahydrocannabinolic Acid (THC-a)
  • Receptors associated with Tetrahydrocannabinolic Acid (THC-a)
  • Individual study details for Tetrahydrocannabinolic Acid (THC-a)

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Overview - Tetrahydrocannabinolic Acid (THC-a)

Description of Tetrahydrocannabinolic Acid (THC-a)

Delta 9-Tetrahydrocannabinolic Acid (Delta-9-THC-A) was discovered in 1969. It is the precursor to THC the primary psychoactive phytocannabinoid.

Other Names:

Delta 9-Tetrahydrocannabinolic Acid

9-carboxy-THC, THC-9-COOH, 9-Carboxy-delta(9)-thc plus numerous other supplier-based synonyms.

IUPAC Name: (6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid

Molecular Formula: C22H30O4


Tetrahydrocannabinolic Acid (THC-a) Properties and Effects

THCA may be:

Tetrahydrocannabinolic Acid (THC-a) Receptor Binding

Endocannabionoid System (ECS) and THC-A: 

Ki is typically measure in the nM range or one billionth. In this case efficacy was measured in μM or one millionth. The reader is reminded that the smaller the Ki the stronger the efficacy.

Other trials suggest mixed results indicating possible tissue specific activation (i.e. positive agonism at peripheral CB1 but not central CB1 activation) (X. Nadal et al., 2017)

Endocannabionoidome (eCBome) and THC-A: 

Ki legend:

  • Full/strong agonist Ki ~1-9nM

  • Moderate agonist Ki ~10-99nM

  • Weak agonist Ki ~100-999nM

  • Very weak agonist Ki ~1,000-up nM

(The reader is reminded that a smaller Ki is associated with the strongest effects.)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.