Tetrahydrocannabinolic Acid (THC-a) Cannabinoid Research

Tetrahydrocannabinolic Acid (THC-a) Research Dashboard


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CannaKeys has 68 studies associated with Tetrahydrocannabinolic Acid (THC-a).

Here is a small sampling of Tetrahydrocannabinolic Acid (THC-a) studies by title:

Components of the Tetrahydrocannabinolic Acid (THC-a) Research Dashboard

  • Top medical conditions associated with Tetrahydrocannabinolic Acid (THC-a)
  • Proven effects in clinical trials for Tetrahydrocannabinolic Acid (THC-a)
  • Receptors associated with Tetrahydrocannabinolic Acid (THC-a)
  • Individual study details for Tetrahydrocannabinolic Acid (THC-a)

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Overview - Tetrahydrocannabinolic Acid (THC-a)

Description of Tetrahydrocannabinolic Acid (THC-a)

Delta 9-Tetrahydrocannabinolic Acid (Delta-9-THCA) was discovered in 1969. It is the precursor to THC, the primary psychoactive phytocannabinoid. However, in its acid form, Delta-9-THCA is non-psychoactive.

Delta-9-THCA is found in fresh cannabis leaves, flowers, and related products. It becomes progressively decarboxylated and thus psychoactive during drying and when exposed to significant heat when heat-processed into oils or smoked. 

Delta-9-THCA is better absorbed systemically than THC (M. Hannon et al., 2020). 

Delta-9-THCA can penetrate the blood-brain barrier (BBB) and induce therapeutic effects on the central nervous system (CNS) (J. Kim et al., 2023)


Other Names:

Delta 9-Tetrahydrocannabinolic Acid

9-carboxy-THC, THC-9-COOH, 9-Carboxy-delta(9)-thc plus numerous other supplier-based synonyms.

IUPAC Name: (6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid

Molecular Formula: C22H30O4


Tetrahydrocannabinolic Acid (THC-a) Properties and Effects

Only Members can view Properties and Effects information. See DEMO page.

Tetrahydrocannabinolic Acid (THC-a) Receptor Binding

Only Members can view Receptor Binding information. See DEMO page.

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.