Unlocking the Science of Cannabis
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Tetrahydrocannabinolic Acid (THC-a) studies by title:
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Delta 9-Tetrahydrocannabinolic Acid (Delta-9-THC-A) was discovered in 1969. It is the precursor to THC the primary psychoactive phytocannabinoid.
9-carboxy-THC, THC-9-COOH, 9-Carboxy-delta(9)-thc plus numerous other supplier-based synonyms.
IUPAC Name: (6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
Molecular Formula: C22H30O4
Ki is typically measure in the nM range or one billionth. In this case efficacy was measured in μM or one millionth. The reader is reminded that the smaller the Ki the stronger the efficacy.
Other trials suggest mixed results indicating possible tissue specific activation (i.e. positive agonism at peripheral CB1 but not central CB1 activation) (X. Nadal et al., 2017)
(The reader is reminded that a smaller Ki is associated with the strongest effects.)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.