SR-x Synthetic Cannabinoids Cannabinoid Research

SR-x Synthetic Cannabinoids Research Dashboard

55

Primary Studies

141

Related Studies

196

Total Studies

Clinical Studies

0

Clinical Meta-analyses

1

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

36

Animal studies

11

Laboratory studies

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CannaKeys has 196 studies associated with SR-x Synthetic Cannabinoids.

Here is a small sampling of SR-x Synthetic Cannabinoids studies by title:


Components of the SR-x Synthetic Cannabinoids Research Dashboard

  • Top medical conditions associated with SR-x Synthetic Cannabinoids
  • Proven effects in clinical trials for SR-x Synthetic Cannabinoids
  • Receptors associated with SR-x Synthetic Cannabinoids
  • Individual study details for SR-x Synthetic Cannabinoids

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Overview - SR-x Synthetic Cannabinoids

Description of SR-x Synthetic Cannabinoids

Rimbonant was first described marketed by Sanofi as a drug to combat obesity. Also known as SR-141716A the compound is an orally active selective antagonist at CB1 receptor sites. Rimonabant was sold as an effective weight loss drug in Europe until adverse effects (e.g., depression and suicidal tendencies) forced their makers to pull the drug from the market. It is extensively used to research the function of the endocannabinoid system (ECS).


Here we focus on SR-141716A.


Another members of of note is SR144528, a full antagonist at CB2 (M. Rinaldi-Carmona et al., 1998).

Other Names:

SR Family Synthetic Cannabinoids

Rimonabant, SR 141716, SR141716A, SR-141716A (plus other supplier-based synonyms)


IUPAC Name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide


Molecular Formula: C22H21Cl3N4O


Source–PubChem

SR-x Synthetic Cannabinoids Properties and Effects

Rimonabant (SR-141716) may: 


  • Induce gastrointestinal difficulties, anxiety, depression and/or suicidal ideations (E. Topol et al., 2022)

  • Prevent methamphetamine neurotoxicity (M. Khodamoradi et al., 2022)

  • Inhibit damage, inflammation, and fibrosis, and cancer-causing pathways in the liver (N. Helmrich et al., 2021)

  • Prevents myotube atrophy with potential relevance in the treatment of sarcopenia (O. Le Bacquer et al., 2021)

  • Suppress hepatitis B virus (HBV) propagation (A. Sato et al., 2020)

  • Rimonabant and THCV reduced weight gain partially modulated via GPR55 (E. Wargent et al., 2020)

  • Represent a novel treatment molecule for patients with Duchenne muscular dystrophy (Fabio A. Lannotti et al., 2018)

  • Rimonabant directly inhibits the Gαi/o protein (Alessandra Porcu et al., 2018)

  • Alters gut microbiota, reduce inflammation and diet-induced obesity (P. Mehrpouya-Bahrami et al., 2017)

  • Contribute to the underlying pathology of polycystic ovary syndrome (T. Sathyapalan et al., 2017)

  • Protect against stroke (Z. W. Reichenbach et al., 2016)

  • Reverses alterations in animal model of Fragile X Syndrome (M. Gomis-González et al., 2016)

  • Decrease symptoms of Parkinson's when co-adm. with L-DOPA (A. Gutiérrez-Valdez et al., 2013)

  • Protect against alcoholic-induced fibrosis (E. Patsenker et al., 2011)

  • Induce anxiety, depression and/or suicidal ideations (E. Topol et al., 2010; A. King 2010)

  • Protect against psychosis (D. Parolaro et al., 2010)

  • Decrease nicotine addiction (B. Le Foll et al., 2009; C. Cohen et al., 2005)

  • Be useful in treating patients with hemorrhagic shock (Li-chao Hou et al., 2009; M. Cainazzo et al., 2002; J. Wagner et al., 1997)

  • Reduce alcohol dependence (K. Yaragudri Vinod et al., 2008)

  • Inhibits human breast cancer cell growth (D. Sarnataro et al., 2006)

  • Inhibit lipopolysaccharide-induced inflammation (S. Raduner et al., 2006)

  • Reduce opioid dependence (M. Mas-Nieto et al. 2001; T. Rubino et al., 2000)

SR-x Synthetic Cannabinoids Receptor Binding

Endocannabinoid System (ECS) and SR-141716A: 


  • CB1 full antagonist with a of Ki ~2nM (M. Rinaldi-Carmona et al., 1994)


Endocannabinoidome (eCBome) and SR-141716A: 


  • Mu-opioid receptors antagonists (Kathryn A. Seely et al., 2012)

  • Modulator at GPR55 (E. Wargent et al., 2020)

  • Positive allosteric modulators of GABA(A) receptors (R. Baur et al., 2012) 




Ki legend:



  • Full/strong agonist Ki ~1-9nM

  • Moderate agonist Ki ~10-99nM

  • Weak agonist Ki ~100-999nM

  • Very weak agonist Ki ~1,000-up nM


(The reader is reminded that a smaller Ki is associated with the strongest effects.)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.