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Here is a small sampling of Phytol studies by title:
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Phytol is a terpene richly represented in nature as part of the larger molecule chlorophyll, which gives leaves their green color and is essential in photosynthesis. As chlorophyll breaks down, phytol is released. It is estimated that about 30% of chlorophyll is phytol.
It is used in many household products like cosmetics, fragrances, shampoos, soaps, and cleaners.
Phytol may have effects that are anti-inflammatory, antioxidant, anti-convulsant, antimicrobial (Staphylococcus aureus), neuroprotective, anti-parasitical (malaria), antihyperglycemic, anti-obesity, pain-reducing, anxiolytic (anti-anxiety), sedating, and may help destroy some types of cancer cells in vitro (adenocarcinoma, hepatocellular).
Is Phytol safe?
Phytol is a clear, colorless, oily liquid. In concentrated forms, it can cause skin irritation.
IUPAC Name: (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol
Floral, Jasmine, Jasmine green tea, balsam
Green tea, jasmine, olive trees, wild lettuce
OG Kush, Harlequin, Cannatonic, Trident
Phytol is associated with the following properties and effects:
Anti-inflammatory and antioxidant (via regulation of NF- κB and AP-1 activation, inhibits levels of IL-1β, IL-4, and TNF- α, neutrophil migration, reduces reactive oxygen species and reactive nitrogen species level by activating antioxidative defense system (Superoxide dismutase and catalase) and restoring Glutathione S-transferase)
Anticonvulsant, anxiolytic, sedative, and neuroprotective properties (via possible activities on GABA receptors, anticholinesterase, butyrylcholinesterase, β-secretase 1 (BACE1), attenuating macromolecular damage, antioxidant activities, and regulating apoptosis-mediated cell death)
Antimicrobial against Staphylococcus aureus and Pseudomonas aeruginosa (via inducing oxidative stress response in P. aeruginosa and damage to the cell membranes with bactericidal activity against S. aureus)
Anti-parasitical against schistosomiasis and Plasmodium berghei (via reducing worm burden, egg laying, suppresses parasitemia, reduces anemia, and oxidative brain damage in test animals infected with Plasmodium berghei)
A potential antihyperglycemic and antiobesity agent may improve oral glucose tolerance and increase brown adipocytes (via PPAR-α and -γ binding)
Pain-reducing (via central and peripheral actions, antioxidant properties)
Anticancer and anti-drug resistance activities. It may help destroy some types of adenocarcinoma, hepatocellular, lung, and skin epidermal cancer cells in vitro and ex-vivo.
It prevents drug resistance in AML models. However, it may also cause selective midzonal hepatocellular necrosis in mice (via apoptosis induction through activation of caspase-9/3 and inhibition of EMT in hepatocellular carcinoma cells, apoptosis in human gastric adenocarcinoma AGS cells through downregulation of Bcl-2, upregulation of Bax, the activation of caspase-9 and -3, PARP cleavage, and depolarization of the mitochondrial membrane, suppresses the P-gp expression via NF-κB inhibition in AML, interactions with β-C, AO-(2) and P may cause induction of apoptosis on A431 and HaCaT cells, antioxidant activities)
Last reviewed by Dr. Abraham Benavides, M.D., 05-27-2022
Endocannabinoid System (ECS) and Phytol:
Endocannabinoidome (eCBome) and Phytol:
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.