ß-Caryophyllene – Terpenes and Cannabinoid Research

ß-Caryophyllene Research Dashboard

69

Primary Studies

14

Related Studies

83

Total Studies

Clinical Studies

3

Double-blind, placebo-controlled human trials

0

Clinical human trials

Pre-Clinical Studies

8

Meta-analyses/Reviews

32

Animal studies

26

Laboratory studies

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ß-Caryophyllene Has Shown Proven Effects in Clinical Human Trials for:

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69 PRIMARY STUDIES | 83 TOTAL STUDIES

Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

Type of Study: Laboratory Study

Year of Pub: 2021

β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease

Type of Study: Animal Study

Year of Pub: 2021

The antimicrobial effect behind Cannabis sativa

Type of Study: Meta-analysis

Year of Pub: 2021

Healing activity of hydrogel containing nanoemulsified β-caryophyllene

Type of Study: Animal Study

Year of Pub: 2020

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

Type of Study: Meta-analysis

Year of Pub: 2020

Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders

Type of Study: Meta-analysis

Year of Pub: 2019

The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice

Type of Study: Animal Study

Year of Pub: 2019

Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection: A Randomized Double-blind, Placebo-controlled Study

Type of Study: Double Blind Human Trial

Year of Pub: 2019

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

Type of Study: Animal Study

Year of Pub: 2019

Excito-repellent Activity of β-Caryophyllene Oxide Against Aedes Aegypti and Anopheles Minimus

Type of Study: Animal Study

Year of Pub: 2019

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Type of Study: Meta-analysis

Year of Pub: 2019

Beta-caryophyllene enhances wound healing through multiple routes

Type of Study: Animal Study

Year of Pub: 2019

Betacaryophyllene – A phytocannabinoid as potential therapeutic modality for human sepsis?

Type of Study: Meta-analysis

Year of Pub: 2018

β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity.

Type of Study: Laboratory Study

Year of Pub: 2018

Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide).

Type of Study: Laboratory Study

Year of Pub: 2018

Hypocholesterolemic effect of β-caryophyllene in rats fed cholesterol and fat enriched diet.

Type of Study: Animal Study

Year of Pub: 2018

Monoamine Involvement in the Antidepressant-Like Effect of β-Caryophyllene.

Type of Study: Animal Study

Year of Pub: 2018

Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.

Type of Study: Animal Study

Year of Pub: 2018

Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion.

Type of Study: Animal Study

Year of Pub: 2018

Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm.

Type of Study: Laboratory Study

Year of Pub: 2018

Ethnopharmacology of Love.

Type of Study: Meta-analysis

Year of Pub: 2018

The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation.

Type of Study: Laboratory Study

Year of Pub: 2018

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

Type of Study: Meta-analysis

Year of Pub: 2018

Synergistic Interaction of β-Caryophyllene With Aromadendrene Oxide 2 and Phytol Induces Apoptosis on Skin Epidermoid Cancer Cells

Type of Study: Laboratory Study

Year of Pub: 2018

The Anti-Inflammatory Properties of Terpenoids from Cannabis

Type of Study: Animal Study

Year of Pub: 2018

Beta-caryophyllene Protects Against Alcoholic Steatohepatitis By Attenuating Inflammation And Metabolic Dysregulation In Mice

Type of Study: Animal Study

Year of Pub: 2017

Inhibitory Effect Of Trans-caryophyllene (TC) On Leukocyte-endothelial Attachment

Type of Study: Laboratory Study

Year of Pub: 2017

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Type of Study: Animal Study

Year of Pub: 2017

Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease. Induced by MPTP.

Type of Study: Animal Study

Year of Pub: 2017

β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis.

Type of Study: Animal Study

Year of Pub: 2017

The cannabinoid beta-caryophyllene (BCP) induces neuritogenesis in PC12 cells by a cannabinoid-receptor-independent mechanism.

Type of Study: Laboratory Study

Year of Pub: 2017

Pharmacokinetic Evaluation of β-Caryophyllene Alcohol in Rats and Beagle Dogs

Type of Study: Animal Study

Year of Pub: 2017

Chemical Composition, Antibacterial Activity, and Synergistic Effects with Conventional Antibiotics and Nitric Oxide Production Inhibitory Activity of Essential Oil from Geophila repens (L.) I.M. Johnst

Type of Study: Laboratory Study

Year of Pub: 2017

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines

Type of Study: Laboratory Study

Year of Pub: 2017

The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration.

Type of Study: Animal Study

Year of Pub: 2016

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties.

Type of Study: Meta-analysis

Year of Pub: 2016

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease.

Type of Study: Animal Study

Year of Pub: 2016

β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn.

Type of Study: Animal Study

Year of Pub: 2016

Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil.

Type of Study: Laboratory Study

Year of Pub: 2016

β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes.

Type of Study: Laboratory Study

Year of Pub: 2016

Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.

Type of Study: Animal Study

Year of Pub: 2016

Use of β-caryophyllene to combat bacterial dental plaque formation in dogs

Type of Study: Animal Study

Year of Pub: 2016

Physicochemical characterization and analgesic effect of inclusion complexes of essential oil from Hyptis pectinata L. Poit leaves with β-cyclodextrin.

Type of Study: Animal Study

Year of Pub: 2015

The Anticancer, Antioxidant And Antimicrobial Properties Of The Sesquiterpene β-Caryophyllene From The Essential Oil Of Aquilaria Crassna

Type of Study: Laboratory Study

Year of Pub: 2015

β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet-induced obese C57BL/6N mice.

Type of Study: Animal Study

Year of Pub: 2015

Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells.

Type of Study: Laboratory Study

Year of Pub: 2015

β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway.

Type of Study: Animal Study

Year of Pub: 2014

β-Caryophyllene, A CB2 Receptor Agonist Produces Multiple Behavioral Changes Relevant To Anxiety And Depression In Mice

Type of Study: Animal Study

Year of Pub: 2014

Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells.

Type of Study: Laboratory Study

Year of Pub: 2014

A role for trans-caryophyllene in the moderation of insulin secretion.

Type of Study: Laboratory Study

Year of Pub: 2014

Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)

Type of Study: Laboratory Study

Year of Pub: 2013

Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.

Type of Study: Animal Study

Year of Pub: 2013

Composition and in vitro anticancer activities of the leaf essential oil of Neolitsea variabillima from Taiwan.

Type of Study: Laboratory Study

Year of Pub: 2013

β-caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.

Type of Study: Animal Study

Year of Pub: 2013

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

Type of Study: Animal Study

Year of Pub: 2013

Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.

Type of Study: Animal Study

Year of Pub: 2013

Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.

Type of Study: Double Blind Human Trial

Year of Pub: 2012

Chemical and biological analyses of the essential oils and main constituents of Piper species.

Type of Study: Laboratory Study

Year of Pub: 2012

b-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.

Type of Study: Laboratory Study

Year of Pub: 2011

β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway.

Type of Study: Animal Study

Year of Pub: 2011

Screening for Antiviral Activities of Isolated Compounds from Essential Oils

Type of Study: Laboratory Study

Year of Pub: 2011

Beta-caryophyllene Is A Dietary Cannabinoid

Type of Study: Animal Study

Year of Pub: 2008

Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.

Type of Study: Laboratory Study

Year of Pub: 2008

Antimutagenic and mutagenic activities of some terpenes in the bacterial reverse mutation assay

Type of Study: Laboratory Study

Year of Pub: 2008

Potentiating Effect Of Beta-caryophyllene On Anticancer Activity Of Alpha-humulene, Isocaryophyllene And Paclitaxel

Type of Study: Laboratory Study

Year of Pub: 2007

Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division.

Type of Study: Laboratory Study

Year of Pub: 2006

Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.

Type of Study: Laboratory Study

Year of Pub: 1999

Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene.

Type of Study: Animal Study

Year of Pub: 1996

Inhalation Of Vapor From Black Pepper Extract Reduces Smoking Withdrawal Symptoms

Type of Study: Double Blind Human Trial

Year of Pub: 1994

14 RELATED STUDIES | 83 TOTAL STUDIES

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

Type of Study: Meta-analysis

Year of Pub: 2019

Sesquiterpenes α-Humulene and β-Caryophyllene Oxide Enhance the Efficacy of 5-fluorouracil and Oxaliplatin in Colon Cancer Cells

Type of Study: Laboratory Study

Year of Pub: 2019

Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects

Type of Study: Double Blind Human Trial

Year of Pub: 2018

Cannabis Therapeutics and the Future of Neurology

Type of Study: Meta-analysis

Year of Pub: 2018

Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis.

Type of Study: Meta-analysis

Year of Pub: 2018

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort

Type of Study: Meta-analysis

Year of Pub: 2018

Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges.

Type of Study: Meta-analysis

Year of Pub: 2017

Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis.

Type of Study: Meta-analysis

Year of Pub: 2017

Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review.

Type of Study: Meta-analysis

Year of Pub: 2017

Terpene Synthases From Cannabis Sativa

Type of Study: Laboratory Study

Year of Pub: 2017

The emerging role of the endocannabinoid system in the pathogenesis and treatment of kidney diseases.

Type of Study: Meta-analysis

Year of Pub: 2015

Camphene, a Plant-Derived Monoterpene, Reduces Plasma Cholesterol and Triglycerides in Hyperlipidemic Rats Independently of HMG-CoA Reductase Activity.

Type of Study: Animal Study

Year of Pub: 2011

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

Type of Study: Meta-analysis

Year of Pub: 2009

Composition and antimalarial activity in vitro of the essential oil of Tetradenia riparia.

Type of Study: Laboratory Study

Year of Pub: 1997

Overview - ß-Caryophyllene

ß-Caryophyllene

Beta-caryophyllene is a sesquiterpene that binds with CB2 receptors. Depending on concentration, its scent is described as spicy, peppery, with a strong warm, wooden aroma and an undertone of citrus.It is not uncommon for beta-caryophyllene to be the predominant terpenoid in cannabis.

Description of ß-Caryophyllene and Cautions

Beta-caryophyllene is a colorless and slightly oily liquid that has been approved by the FDA as a food additive for human consumption (FDA PART 172).

Scent Description

Black pepper, cloves, hops, cinnamon

Natural Sources

Black pepper, grains of Paradise, basil, Sri Lankan cinnamon, caraway

Summary of ß-Caryophyllene Effects

Immune-modulation, anti-inflammatory, neuroprotective (spasms, seizures, epilepsy, induces neuritogenesis); may protect from Alzheimer’s Disease and Vascular Dementia; may be beneficial in cases of colitis, IBS; anti-bacterial (tuberculosis, leprosy, Staphylococcus aureus, Pseudomonas aeruginosa); anti-fungal (Candida albicans, Aspergillus niger); may be protective against type-2 diabetes; may have anti-cancer properties (kidney, colon, pancreatic, melanoma, lymphoma); may produce a synergistic effect with certain chemotherapy agents (e.g. Paclitaxel), analgesic effects (in cases of inflammatory and neuropathic pain), antioxidant, may protect against binge drinking or chronic alcohol consumption-induced alcoholic steatohepatitis,nonalcoholic fatty liver disease, and steatosis (fatty liver diseases).

Cannabis Strains High in ß-Caryophyllene

Tickle Kush, SFV OG, Super Lemon Haze, Sherbert Breath

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.