Pentadecanoylcarnitine (PDC) Cannabinoid Research

Pentadecanoylcarnitine (PDC) Research Dashboard

3

Primary Studies

6

Related Studies

9

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

2

Animal studies

1

Laboratory studies

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CannaKeys has 9 studies associated with Pentadecanoylcarnitine (PDC).

Here is a small sampling of Pentadecanoylcarnitine (PDC) studies by title:


Components of the Pentadecanoylcarnitine (PDC) Research Dashboard

  • Top medical conditions associated with Pentadecanoylcarnitine (PDC)
  • Proven effects in clinical trials for Pentadecanoylcarnitine (PDC)
  • Receptors associated with Pentadecanoylcarnitine (PDC)
  • Individual study details for Pentadecanoylcarnitine (PDC)

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Overview - Pentadecanoylcarnitine (PDC)

Description of Pentadecanoylcarnitine (PDC)

Pentadecanoylcarnitine (PDC) is a novel endocannabinoid (discovered 2022) that is associated with activities relevant to both physical and mental health. PDC is an endogenous metabolite derived from the dietary odd-chain fatty acid pentadecanoic acid (C15:0).

C15:0 occurs naturally (but only in relatively small amounts) in whole fat milk and butter, lard, beef, sheep, fish and fish derived oils; in some vegetables (e.g., cucumber cabbage); and in algae and seaweed.

Large cohort trials have shown that higher dietary intake of C15:0 are associated with a lower overall mortality and increased longevity. C15:0 is available as a dietary supplement and a pre-clinical trial found that is was able to lower glucose, cholesterol, pro-inflammatory cytokines, as well as body weight in a mouse model of obesity and type 2 diabetes.

Other Names:

Pentadecanoylcarnitine
C15 carnitine, pentadecanoylcarnitine, O-pentadecanoylcarnitine

IUPAC Name: 3-pentadecanoyloxy-4-(trimethylazaniumyl)butanoate

Molecular Formula: C22H43NO4

–Source: PubChem

Pentadecanoylcarnitine (PDC) Properties and Effects

Pentadecanoylcarnitine has broad dose-dependent anti-proliferative and anti-inflammatory activities with relevance to chronic inflammation (e.g. dermatitis, psoriasis, wound healing), over-reactive immune responses (e.g., rheumatoid arthritis or other autoimmune disorders), COPD, and cardio-vascular illness.

Pentadecanoylcarnitine (PDC) Receptor Binding

Endocannabinoid system (ECS):
• CB1 [full agonist with a half-maximal effective concentrations (EC50) of 3.7µM see Venn-Watson, 2022]
• CB2 [full agonist with a half-maximal effective concentrations (EC50) of 3.2µM see Venn-Watson, 2022]

Endocannabinoidome (eCBome)
• Histamine H1 (antagonist)
• Histamine H2 (antagonist)
• 5-HT1A (agonist at this serotonin receptor site)
• 5-HT1B (agonist at this serotonin receptor site)

In contrast, pentadecanoic acid (C15:0) the precursor to PDC is a dual, partial PPAR α/δ agonist.

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.