Ocimene Research Dashboard
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Overview - Ocimene
What is Ocimene?
Ocimene has a floral and perfume-like scent and is a flavoring agent and additive.
It is found in relatively low concentrations of cannabis but in higher concentrations in certain essential oils.
Ocimene is thought to possess anticonvulsant activity, antifungal activity, antibacterial activity, potential antihypertensive activity, and antitumor activity.
Is Ocimene safe?
Ocimene is a floral-smelling oil that, in its isolated form, can cause severe eye and skin irritation and can be fatal if aspirated.
Scent Description
Woody, vegetal, herbaceous
Natural Sources
Allspice, tarragon, basil, mint, parsley
Cannabis Cultivars High in Ocimene
Ghetto Bird, Medicine Man, Pineapple Upside Down Cake, Phone Home, Pineapple Fields, Deep Breath, Durban Poison, Dutch Treat, Chocolope
Ocimene Properties and Effects
Ocimene is associated with the following properties and effects:
- Anti-seizure (C. Okoli et al., 2010)
- Anxiolytic (C. Okoli et al., 2010)
Anti-inflammatory (via nitric oxide (NO) production inhibition, NO scavenging effect, and inhibited inducible NO synthase expression)
Anti-oxidant (via antiradical activity concerning OH and preventing the initiation of hydroxyl and superoxide radicals)
Anti-bacterial (via inhibiting growth of Proteus mirabilis, Staphylococcus aureus, Corynebacterium pseudotuberculosis, Klebsiella pneumonia, Pseudomonas aeruginosa, Enterobacter aerogenes, Salmonella enterica, and Streptococcus pyogenes when compared to standard antibiotics for positive control)
Anti-fungal (via inhibiting growth of dermatophytes and Cryptococcus neoformans)
Anti-tumor activity (via cytotoxicity in vitro on cancer cell lines of B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia)
Possibly anticonvulsant and anxiolytic (via possible enhancement of GABAergic transmission)
Potentially anti-hypertensive and antidiabetic (via antioxidant activity, co-occurring phenolic content of ocimene-containing compounds like black pepper, and inhibiting α -amylase, α -glucosidase, and ACE enzyme activities in concentration-dependent manners)
Last reviewed by Dr. Abraham Benavides, M.D., 05-20-2022
Ocimene Receptor Binding
Endocannabinoid System (ECS) and Ocimene:
- CB1 (agonist) (N. Raz et al., 2023)
Endocannabinoidome (eCBome) and Ocimene:
N/A
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
