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N-Arachidonoyl Dopamine (NADA) Cannabinoid Research

N-Arachidonoyl Dopamine (NADA) Research Dashboard

25

Primary Studies

7

Related Studies

32

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

6

Animal studies

17

Laboratory studies

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CannaKeys has 32 studies associated with N-Arachidonoyl Dopamine (NADA).

Here is a small sampling of N-Arachidonoyl Dopamine (NADA) studies by title:

  • Influence of N-Arachidonoyl Dopamine and N-Docosahexaenoyl Dopamine on the Expression of Neurotrophic Factors in Neuronal Differentiated Cultures of Human Induced Pluripotent Stem Cells under Conditions of Oxidative Stress
  • Neuroprotective and neurotoxic effects of endocannabinoid-like compounds, N-arachidonoyl dopamine and N-docosahexaenoyl dopamine in differentiated cultures of induced pluripotent stem cells derived from patients with Parkinson's disease
  • N-arachidonoyl dopamine inhibits epithelial-mesenchymal transition of breast cancer cells through ERK signaling and decreasing the cellular cholesterol
  • Early-life N-arachidonoyl-dopamine exposure increases antioxidant capacity of the brain tissues and reduces functional deficits after neonatal hypoxia in rats
  • N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1

Components of the N-Arachidonoyl Dopamine (NADA) Research Dashboard

  • Top medical conditions associated with N-Arachidonoyl Dopamine (NADA)
  • Proven effects in clinical trials for N-Arachidonoyl Dopamine (NADA)
  • Receptors associated with N-Arachidonoyl Dopamine (NADA)
  • Individual study details for N-Arachidonoyl Dopamine (NADA)

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Overview - N-Arachidonoyl Dopamine (NADA)

Description of N-Arachidonoyl Dopamine (NADA)

N-acyldopamines are a group of endocannabinoids of which N-arachidonoyl dopamine (NADA) is one of its most prominent and most studied members.

NADA is present in very low concentrations in various portions of the brain such as the striatum, hippocampus, cerebellum, thalamus, midbrain, and dorsal root ganglia for example.

Additionally a novel class of synthetic anandamide (AEA) analogues were described by a group of Italian researchers (T. Bisogno et al., 2000).

Other Names:

N-Arachidonoyl Dopamine
Arachidonoyl dopamine, N-Arachidonyldopamine, NADA dopamine and others.

IUPAC Name: (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide

Molecular Formula: C28H41NO3

Source–PubChem

N-Arachidonoyl Dopamine (NADA) Properties and Effects

• In vivo effects of NADA included hypothermia, hypo-locomotion, catalepsy and analgesia in the test animals.
• NADA was a significant inhibitor of human breast MCF-7 cancer cells.
• NADA has shown to induce anti-oxidative properties.
• NADA is neuroprotective.
• NADA modulates immune cells
• NADA mediates vasorelaxation.
• NADA inhibited aggregation of human platelets.

N-Arachidonoyl Dopamine (NADA) Receptor Binding

Endocannabinoid system (ECS):
• NADA is an agonist at CB1 (Ki ~0.25 see Bisogno T. 2000)
• NADA is an agonist at CB2 (Ki ~12 see Bisogno T. 2000)
• NADA was shown to be an inhibitor of FAAH (Urszula Grabiec et al. 2017)
• NADA was shown to be an inhibitor of MAGL (E Björklund et al. 2010)

Endocannabinoidome (eCBome)
• NADA is a potent agonist of TRPV1 (Urszula Grabiec et al. 2017)
• NADA may be an antagonist at TRPM8 (Luciano De Petrocellis et al. 2007)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.