Lysophosphatidylinositol (LPI) Cannabinoid Research

Lysophosphatidylinositol (LPI) Research Dashboard


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CannaKeys has 28 studies associated with Lysophosphatidylinositol (LPI).

Here is a small sampling of Lysophosphatidylinositol (LPI) studies by title:

Components of the Lysophosphatidylinositol (LPI) Research Dashboard

  • Top medical conditions associated with Lysophosphatidylinositol (LPI)
  • Proven effects in clinical trials for Lysophosphatidylinositol (LPI)
  • Receptors associated with Lysophosphatidylinositol (LPI)
  • Individual study details for Lysophosphatidylinositol (LPI)

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Overview - Lysophosphatidylinositol (LPI)

Description of Lysophosphatidylinositol (LPI)

Lysophosphatidylinositol (LPI) is a bioactive lipid produced by the phospholipase A (PLA) family of lipases. LPI is posited to play a significant role in diverse physiological and pathological processes.

LPI is a proposed endogenous ligand/agonist for GPR55 (Roberto Piñeiro et al. 2012)

2-arachidonoyl lysophosphatidylinositol (2-ALPI)

2-LPI is a proposed endogenous ligand/agonist for GPR55 (Saori Oka et al. 2009)

Other Names:


LPI: L-alpha-lysophosphatidylinositol; L-α-lysophosphatidylinositol

LPI IUPAC Name: [(2S)-2-hydroxy-3-[hydroxy-[(2R,3S,5R,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxypropyl] acetate

LPI Molecular Formula: C11H21O12P

2-ALPI: 2-arachidonoyl-LPI; 2-arachidonoyl-lysophosphatidylinositol; 2-arachidonoyl-sn-glycero-3-phospho-D-myo-inositol 4,5-bisphosphate

2-ALPI IUPAC Name: [(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4-[[(2R)-3-hydroxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxypropoxy]-oxidophosphoryl]oxy-6-phosphonatooxycyclohexyl] phosphate

2-ALPI Molecular Formula: C29H46O18P3-5


Lysophosphatidylinositol (LPI) Properties and Effects

The LPI/GPR55 axis: 

  • May worsen metabolic disorders (e.g., obesity, diabetes, inflammation)

  • May worsen developments and metastasis of certain cancer (e.g., breast cancer, colon cancer, uterine/endometrial cancer)

  • May worsen non-alcoholic steatosis & steatohepatitis

  • May worsen myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway

  • Inflammation (mixed results with some studies suggesting pro- vs anti-inflammatory effects)


Lysophosphatidylinositol (LPI) Receptor Binding

Endocannabinoid System (ECS) and LPI/2-LPI:

  • N/A

Endocannabinoidome (eBCome)and LPI/2-LPI:

  • GPR55 LPI is proposed agonist 

  • GPR55 2-LPI is proposed agonist

  • LPI activates TRPV2 (Kazuki Harada et al. 2017)

Inhibitors of LPI:

  • Δ9-tetrahydrocannabivarin, cannabidivarin, and cannabigerovarin (Sharon Anavi-Goffer et al. 2012); CBD (E Ryberg et al. 2007)

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.