Linalool – Terpenes and Cannabinoid Research

Linalool Research Dashboard

96

Primary Studies

13

Related Studies

109

Total Studies

Clinical Studies

2

Clinical Meta-analyses

14

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

16

Meta-analyses/Reviews

30

Animal studies

32

Laboratory studies

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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 109 studies associated with Linalool.

Here is a small sampling of Linalool studies by title:


Components of the Linalool Research Dashboard

  • Top medical conditions associated with Linalool
  • Proven effects in clinical trials for Linalool
  • Receptors associated with Linalool
  • Individual study details for Linalool

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Overview - Linalool

What is Linalool?

Linalool is a simple terpene that offers a floral, lavender-like scent with a hint of spiciness.


Silexan is an over-the-counter lavender preparation high in linalool with supporting studies for anxiety.


Linalool can act on many receptors and pathways, thus displays a vast array of potential effects, including anticancer, antimicrobial, neuroprotective, anti-dementia, anticonvulsant, anxiolytic, antidepressant, antioxidant, anti-inflammatory, analgesic, anti-obesity, antihypertensive, antihyperlipidemic, anti-stress, chemo-synergistic, cardioprotective, hepatoprotective, renal protective, and lung protective activities.


Is Linalool safe?


The isolated terpene is a colorless liquid and may cause skin, eye, and respiratory irritation and allergic reactions.


 

Other Names

IUPAC Name: 3,7-dimethylocta-1,6-dien-3-ol 


Source–PubChem


 

Scent Description

Lavender, floral, rose, lemon, coriander

Natural Sources

Lavender, coriander, cinnamon, mint, bergamot oranges, frankincense

Cannabis Strains High in Linalool

Fire OG, Diamond Girl, Trainwreck, LA Confidential, Purple Kush, White Cookies, Valley Fire, Conspiracy Kush, Jilly Bean, Jack Cleaner 2, Jack Skellington, Nordle and Nurse Jackie

Linalool Properties and Effects

Linalool is associated with the following properties and effects:



  1. Anti-cancer 

    1. Apoptotic (to breast cancer cell lines) (H. Elbe et al., 2022)



  2. Anti-depressant (É. Quaresma Dos Santos et al., 2022)

  3. Anti-microbial 

    1. Anthelmintic (against Hyalomma scupense) (D. Alimi et al., 2022)

    2. Anti-bacterial (against Klebsiella pneumoniae) (Shun-Kai Yang et al., 2022)




Anticonvulsant


Neuroprotective


Anti-Alzheimer’s effects and anti-parkinsonian in animal models (via GABAergic transmission, suppressing ROS, antioxidant activity, anticholinesterase activity, reducing Aβ42-induced oxidative stress and inflammatory reactions, reversing the histopathological hallmarks of AD and restoring cognitive and emotional functions, reducing dementia-associated symptoms such as agitation, aggression, and restlessness, mitochondrial activity and regulation by gas-1, nuo-1, and mev-1, increased seizure latency period, reducing the frequency and intensity of convulsions, protective against clonic and tonic convulsions)


Anxiolytic, antidepressant, anti-stress, sedative (via benzodiazepine-responsive GABAA receptors, inhibiting voltage-dependent calcium channels, may increase serotonin levels and decrease cortisol levels)


Anti-inflammatory and antioxidant (via COX-2 inhibition, free radical scavenging, reduces oxidative stress)


Antibacterial against G. vaginalis, P. aeruginosa, K. pneumoniae, including uropathogenic, carbapenemase-producing, and metallo-β-lactamase-1-producing strains, as well as sensitive and drug-resistant S. aureus, MRSA, and E. Coli, anti-microbial, anti-candidal, anti-parasitic (leishmania), acaricidal (ticks), nematocidal, and anthelmintic (via inhibiting bacterial growth and biofilm formation, disruption of bacterial cell membranes, drug resistance-reversing effect against resistant and sensitive E. coli, moderate efflux pump inhibition on MRSA strains, inhibiting H+ extrusion through ATPase, synergistic action with azoles, inhibitory effect on fungal mycelial growth, and antifungal mechanisms yet to be determined)


Antihyperlipidemic, cardioprotective, may be antihypertensive (via reducing total cholesterol and triglyceride levels, reducing LDL cholesterol levels while increasing HDL levels, improving lipid metabolism, reducing systolic blood pressure, reducing pulse rates, suppressing atherogenic index and cardiac risk factors in mice)


Anti-obesity agent reduces the weight of white adipose tissue in mice (via PPARα binding, modulating fatty acid uptake, fatty acid oxidation, promoting lipolysis, managing leptin, upregulating energy metabolism, decreasing oxidative stress, and inhibiting the occurrence of obesity in mice, decreasing body weight, fat accumulation, and reducing the average body weight of mice)


Various organ and cell-protective effects such as hepatoprotective, renal protective, lymphocyte protective, and lung protective activity in the setting of respiratory disorders, may protect against IBS-related spasticity, may protect against gastric ulcers, may be suitable for use as an adjunct to intravesical therapy of interstitial cystitis (via antiinflammatory actions, inhibiting ACE2 activity, inhibiting cholinergic- and non-cholinergic-mediated gut contractions in mice, decreasing triglyceride levels, decreasing pro-inflammatory cytokine mRNA expression and decreasing IL-8 secretion in T24 human bladder cells)


Antinociceptive and analgesic may produce synergistic analgesic effects with opioids and may reduce the need for opioids in the post-op period (via acting on voltage-dependent Na+ channels, inhibiting nociceptive stimulus-induced inflammatory infiltrates, GABA- and glycine-mimetic effects, the activity of adenosine A1 and A2A receptors, blocking nitric oxide synthesis, suggested involvement of opioid receptors, dopaminergic transmission via D2 receptors, muscarinic M2 receptors, downstream potassium channel opening, and COX-2 overexpression)


Anticarcinogenic and antiproliferative effects against certain cancer cell lines may protect against certain cancers such as kidney, breast, lymphoma, leukemia, lung, oral, colon, skin, sarcoma, cervical, and liver (via inducing cell cycle arrest and oxidative stress, inducing cell cycle arrest and apoptosis with the involvement of Ras, MAPKs, Akt/mTOR, and JAK2/STAT3 pathways plus facilitating the expression of p53, p21, p27, p16, and p18, inducing of apoptosis with a decrease in the expression of p-PI3K, p-AKT, and Bcl-2, rise in the expression of Bax, and lipid peroxidation, causing extensive necrosis and reduced viable tissue mass in vivo, endoplasmic reticulum stress and ribosome biogenesis impairment in AGS cells)


It may produce synergistic effects with certain chemotherapy drugs, may improve drug delivery (via selective cytotoxicity towards tumor cells, protection and sparing of normal cells, modulating oxidative stress, protection against doxorubicin-induced kidney injuries, may reverse doxorubicin resistance, reduce tumor cell viability, tumor volume, tumor weight, and tumor cell count, nano emulsification of chemo drugs, anti-inflammatory protective effects, and low toxicity)


Last reviewed by Dr. Abraham Benavides, M.D., 07-21-2022

Linalool Receptor Binding

Endocannabinoid System (ECS) and Linalool:



  1. CB1 (agonist) (N. Raz et al., 2023)


Endocannabinoidome (eCBome) and Linalool:



  1. Serotonin receptor sites

    1. 5-HT1A (reduced receptor binding) (P. Baldinger et al., 2015)



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Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.