Unlocking the Science of Cannabis
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Fatty Acid-binding Protein (FABP) studies by title:
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Fatty acid-binding proteins (FABPs), a family of proteins sometimes referred to as lipid chaperones, are intracellular proteins that facilitate the transport of AEA to different parts of the human body. Guided by the homeostatic mechanisms on an as-needed basis FABPs transport AEA to a cellular organelle the endoplasmic reticulum (a transport system) where the enzyme FAAH1 is found. Once in proximity, FAAH1 begins to function as a catalyst (to cause the reaction) for AEA's hydrolyses (break down). (M. Elmes et al., 2015)
When cannabinoids such as THC and CBD are present and bind to FABPs instead of AEA, they inhibit AEA's breakdown and, as such, increase its bioavailability. (D. Deutsch, 2016)
To date, 10 different types of FABPs have been identified in humans, each found in specific tissues such as the brain, kidney, or liver for example. Of these three known members, i.e., FABP3, FABP5, and FABP7 bind with THC and CBD. (M. Elmes et al., 2015)
Increases the bioavailability of AEA (D. Deutsch, 2016)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.