Fatty Acid Amide Hydrolase (FAAH) Research Dashboard
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CannaKeys has 312 studies associated with Fatty Acid Amide Hydrolase (FAAH).
Here is a small sampling of Fatty Acid Amide Hydrolase (FAAH) studies by title:
- Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review
- Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone
- Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders
- Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function
- Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort
Components of the Fatty Acid Amide Hydrolase (FAAH) Research Dashboard
- Top medical conditions associated with Fatty Acid Amide Hydrolase (FAAH)
- Proven effects in clinical trials for Fatty Acid Amide Hydrolase (FAAH)
- Receptors associated with Fatty Acid Amide Hydrolase (FAAH)
- Individual study details for Fatty Acid Amide Hydrolase (FAAH)
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Overview - Fatty Acid Amide Hydrolase (FAAH)
Description of Fatty Acid Amide Hydrolase (FAAH)
The naturally occurring enzyme fatty-acid amide hydrolase (FAAH) was discovered in the late nineties (B. Cravat 1996) and is one of the primary compounds responsible for metabolizing (breaking down) bioactive fatty acid amides such as the endocannabinoid anandamide (AEA) to their corresponding acids, thus terminating the signaling functions of these molecules.
The enzyme is primarily found in cells of the central nervous system and, to a lesser degree, in the periphery.
It exists in two forms, FAAH1 and FAAH2 (B. Q. Wei et al., 2006)
FAAH2 was found in several mammalian species but not in all, such as rats and mice, which may account for the often paradoxical results found between animals and human studies testing for the analgesic effects of FAAH inhibitors (B. Q. Wei et al., 2006)
FAAH plays a significant regulatory role within the endocannabinoid system (ECS) that has potential relevance in the clinical setting, modulating mood (e.g., stress, anxiety), energy metabolism, appetite, pain, inflammatory processes, or neurodegeneration, and as such, may benefit many of the conditions that share one or more of these underlying pathologies). Furthermore, several animal trials have shown efficacy in the treatment of different types of pain. As a result, inhibitors of FAAH (e.g., CBD) have generated significant interest in the research community as a potentially novel agent to treat many mainly pain-related conditions. However, researchers found that promising animal trials did not translate to humans.
FAAH levels are also affected by changes to the gene that codes for it. To give the reader a practical idea of the effects of gene-induced low FAAH levels, let us look at this example: An international team of researchers present a curious case study (A. Habib et al., 2019), i.e., of a 60-year-old woman who felt little or no pain (even when injured by burns or cuts), experienced rapid wound healing, and felt no anxiety or depression in all her life. The subsequent test revealed that the patient lacked the gene to produce the enzyme FAAH. As a result, she presented with significantly higher levels of AEA (and related fatty-acid amides such as palmitoylethanolamide and oleoylethanolamine), presumed responsible for her odd presentations.
Other Names:
Fatty Acid Amide HydrolaseFatty-acid amide hydrolase
Fatty Acid Amide Hydrolase (FAAH) Properties and Effects
Inhibition of FAAH is associated with:
- Mood-improving effects (F. Leweke et al., 2012)
- Anti-inflammatory effects
- Analgesia
Fatty Acid Amide Hydrolase (FAAH) Receptor Binding
Not Applicable
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
