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Here is a small sampling of Fatty Acid Amide Hydrolase (FAAH) studies by title:
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This naturally occurring enzyme is one of the primary compounds responsible for metabolizing (break down) bioactive fatty acid amides such as the endocannabinoid anandamide (AEA) to their corresponding acids, thus terminating the signaling functions of these molecules.
To demonstrate the effects of FAAH let us look at what happens when FAAH ceases to function: An international team of researchers present a curious case study (A. Habib et al., 2019) i.e., of a 60-year-old woman who felt little or no pain (even when injured by burns or cuts), experienced rapid wound healing, and felt no anxiety or depression in all her life. Subsequent test revealed the patient lacked the gene to produce the enzyme FAAH and as a result presented with significantly higher levels of AEA (and related fatty-acid amides such as palmitoylethanolamide and oleoylethanolamine) presumed responsible for her odd presentations. This case and the primary studies presented in the CK database describe the scientific context of the role that FAAH, and by extension AEA (and similar compounds), play in the experience of pain, anxiety, and depression for example. For instance, results from a a double-blind, randomized clinical trial demonstrated that CBD inhibits FAAH activity which in turn was associated with a significant clinical improvement in the participating psychiatric patients (F. Leweke et al., 2012).
Fatty-acid amide hydrolase
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.