Cannabidiolic Acid (CBD-a) Research Dashboard
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CannaKeys has 84 studies associated with Cannabidiolic Acid (CBD-a).
Here is a small sampling of Cannabidiolic Acid (CBD-a) studies by title:
- Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
- Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
- Cannabidiol but not cannabidiolic acid reduces behavioural sensitisation to methamphetamine in rats, at pharmacologically effective doses
- The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis
- The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity
Components of the Cannabidiolic Acid (CBD-a) Research Dashboard
- Top medical conditions associated with Cannabidiolic Acid (CBD-a)
- Proven effects in clinical trials for Cannabidiolic Acid (CBD-a)
- Receptors associated with Cannabidiolic Acid (CBD-a)
- Individual study details for Cannabidiolic Acid (CBD-a)
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Overview - Cannabidiolic Acid (CBD-a)
Description of Cannabidiolic Acid (CBD-a)
The isolation and structure of cannabidiolic-acid (CBDA) was described by R. Mechoulam et al., in 1965. The understanding of the pharmacodynamics and -kinetics of CBDA is more limited when compared to CBD.
Other Names:
Cannabidiolic AcidCannabidiolic acid, CBDA
IUPAC Name: 2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-6-pentylbenzoic acid
Molecular Formula: C22H30O4
Source–PubChem
Cannabidiolic Acid (CBD-a) Properties and Effects
CBDA may:
- Prevent as well as treat infection by SARS-CoV-2 (R. van Breemen et al., 2022)
- Reduce biomarkers of stress and inflammation in cattle (M. Kleinhenz et al., 2022)
- Decrease pruritus in dogs with atopic dermatitis when administered with CBD (M. Loewinger et al., 2022)
- Ameliorate obesity and associated metabolic abnormalities (E. Ben-Cnaan et al., 2022; E. D'Aniello et al., 2019)
- Treat chemotherapy-induce nausea and vomiting (E. Rock et al., 2022)
- Suppress genes involved in the metastasis of breast cancer cells (S. Takeda et al., 2014)
- Prevent vomiting (D. Bolognini et al., 2013)
Cannabidiolic Acid (CBD-a) Receptor Binding
The Endocannabinoid system (ECS) and CBDA:
- CB2 weak agonism (A. Zagzoog et al., 2020)
- CB1 inactive (A. Zagzoog et al., 2020)
The Endocannabinoidome (eCBome) and CBDA:
- PPAR-α (alpha) agonists (E. D'Aniello et al., 2019)
- PPAR-γ (gamma) agonists (E. D'Aniello et al., 2019)
- Selective COX-2 inhibitor (S. Takeda et al., 2014)
- Enhances 5-HT1A receptor activation (D. Bolognini et al., 2013)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
