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Bisabolol – Terpenes and Cannabinoid Research

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Overview - Bisabolol

What is Bisabolol?

Bisabolol is a sesquiterpene occurring in significant amounts in several plant species, such as Psidium guajava (guava), Matricaria chamomilla (German chamomile), and cannabis.


Is Bisabolol safe?


Its concentrated form is a clear, colorless liquid that may cause skin irritation and allergic reactions.

Other Names

IUPAC Name: (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol


Source–PubChem

Scent Description

Fruity, nutty aroma with hints of coconut.


Source–PubChem

Natural Sources

Psidium guajava (guava), Matricaria chamomilla (German chamomile), Cannabis.

Cannabis Cultivars High in Bisabolol

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Bisabolol Properties and Effects

Bisabolol may have the following properties and effects:


  1. Analgesia

    1. Antinociceptive (B. Amora-Silva et al., 2019)

    2. Anti-inflammatory (B. Amora-Silva et al., 2019; A. Licari et al., 2017)



  2. Anti-amyloid (against neurotoxic beta-amyloid) (J. Laws Iii et al., 2022)

  3. Anticancer

    1. Anti-metastatic (in pancreatic cancer cells) (M. Uno et al., 2016; Y. Murata et al., 2017)

    2. Anti-tumor (in pancreatic cancer cells) (M. Kano et al., 2023; T. Seki et al., 2011)

    3. Apoptotic (in pancreatic cancer cells) (M. Kano et al., 2023)



  4. Antioxidant (E. Ramazani et al., 2022)

  5. Neuroprotective (H. Javed et al., 2020)

  6. Cardio-protective (M. Nagoor Meeran et al., 2020)

  7. Skin-protective

    1. Wound healing (B. Amora-Silva et al., 2019)

    2. Anti-pruritic

    3. Depigmenting (skin lightening) agent (J. Lee et al., 2010)



  8. Antimicrobial (B. Amora-Silva et al., 2019)


    1. Candida albicans (F. Galvão Rodrigues et al., 2018)

    2. Candida krusei (F. Galvão Rodrigues et al., 2018)

    3. Candida tropicalis (F. Galvão Rodrigues et al., 2018)

    4. Staphylococcus aureus (F. Galvão Rodrigues et al., 2018)



  9. Anti-parasitical

    1. Leishmaniosis (effective in dogs) (V. Corpas-Lopez et al., 2018)



  10. Gastro-protective (N. Moura Rocha et al., 2011)

  11. Nephroprotective (T. Lima Sampaio et al., 2016)

  12. Synergistic analgesia with Tetradrine (may reduce brain cancer metastasis) (L. Jui-Feng et al., 2022)

Bisabolol Receptor Binding

Endocannabinoid System (ECS) and Bisabolol:


N/A


Endocannabinoidome (eCBome) and Bisabolol:



  1. A3 (Adenosine receptor site 3) (F. Brackmann Mendes et al., 2017)

  2. Ca+ (Voltage-gated sodium channel Ca+ channels)

    1. Cav3.2 T-type calcium channels (inhibits) (V. Gadotti et al., 2021)



  3. FAK (focal adhesion kinase is involved in how cells stick together) (Bisabolol inhibits FAK phosphorylation-induces anticancer apoptosis) (M. Kano et al., 2023)

  4. KISS1r (Kisspeptin receptor aka GPR54) (bisabolol activates with potential therapeutic potential for pancreatic cancer) (M. Uno et al., 2016)

  5. MARK (Mitogen-activated protein kinase) (bisabolol inhibits) (B. Venkataraman et al., 2022)

  6. PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) (bisabolol stimulates PPAR-γ expression) (B. Venkataraman et al., 2022)

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Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.