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Palmitoylethanolamide (PEA) Cannabinoid Research

Palmitoylethanolamide (PEA) Research Dashboard

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Overview - Palmitoylethanolamide (PEA)

Description of Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) was identified in 1957. It is a naturally occurring compound made from fat and is produced by mammalian body's for the purpose of tissue repair. More specifically, PEA is an endogenous fatty acid amide formed, as the name implies, by combining a fatty acid with an amine (a family of organic compound containing nitrogen). The compound is one of the most common of the N-acylethanolamines (NAEs) [a family that includes anandamide (AEA) and oleoylethanolamide (OEA) a compound involved in feeling satieted].


PEA is not an endocannabinoid per se because it has no affinity (or only very weak affinity) for the classical endocannabinoid receptor sites CB1 or CB2. However, PEA may be an allosteric (indirect modulator) of CB1 and/or CB2.


PEA modulates other receptor sites that are part of the greater ECS-based environment entitled the endocannabinoidome (see the receptor site window for more information).


Foods that contain PEA include soy, egg yolk, corn, peanuts, pea and bean seeds. PEA was also discovered in human, bovine, and moose milk. Nutraceuticals containing PEA are readily available as oral supplements.

Other Names:

N-hexadecanoylethanolamide

Palmitoylethanolamide, Palmidrol, 544-31-0, N-(2-Hydroxyethyl)hexadecanamide, Palmitoyl ethanolamide


IUPAC Name: N-(2-hydroxyethyl)hexadecanamide


Molecular Formula: C18H37NO2


Source–PubChem

Palmitoylethanolamide (PEA) Properties and Effects

Only Members can view Properties and Effects information. See DEMO page.

Palmitoylethanolamide (PEA) Receptor Binding

Only Members can view Receptor Binding information. See DEMO page.

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.