2-Arachidonoyl Glycerol (2-AG) Cannabinoid Research

2-Arachidonoyl Glycerol (2-AG) Research Dashboard

184

Primary Studies

212

Related Studies

396

Total Studies

Clinical Studies

1

Clinical Meta-analyses

2

Double-blind human trials

12

Clinical human trials

Pre-Clinical Studies

75

Meta-analyses/Reviews

64

Animal studies

30

Laboratory studies

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CannaKeys has 396 studies associated with 2-Arachidonoyl Glycerol (2-AG).

Here is a small sampling of 2-Arachidonoyl Glycerol (2-AG) studies by title:


Components of the 2-Arachidonoyl Glycerol (2-AG) Research Dashboard

  • Top medical conditions associated with 2-Arachidonoyl Glycerol (2-AG)
  • Proven effects in clinical trials for 2-Arachidonoyl Glycerol (2-AG)
  • Receptors associated with 2-Arachidonoyl Glycerol (2-AG)
  • Individual study details for 2-Arachidonoyl Glycerol (2-AG)

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Overview - 2-Arachidonoyl Glycerol (2-AG)

Description of 2-Arachidonoyl Glycerol (2-AG)

Raphaeal Mechoulam's et al., from the Hebrew University, Israel and T. Sugiura et al., from Teikyo University, Japan described the discovery of a second endogenous cannabinoid subsequently named 2-arachidonoylglycerol (2-AG) in 1994-1995.


2-AG is an ester formed from the essential fatty acid omega-6-arachidonic acid and glycerol.


Monoacylglycerol lipase (MAGL) is a key enzyme that metabolizes 2-AG.

Other Names:

2-Arachidonoyl Glycerol

2-Arachidonylglycerol, 2-arachidonoylglycerol, 2-Arachidonoyl Glycerol (and numerous others)


IUPAC Name: 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate


Molecular Formula: C23H38O4


Source–PubChem

2-Arachidonoyl Glycerol (2-AG) Properties and Effects

The Endocannabinoid System (ECS) and 2-AG:


  • 2-AG release plays a role in the rewarding consequences of sexual arousal and orgasm (J. Fuss et al., 2017)


The Endocannabinoidome (eCBome) and 2-AG:

2-Arachidonoyl Glycerol (2-AG) Receptor Binding

Endocannabinoid System (ECS):




Ki legend:



  • Full/strong agonist Ki ~1-9nM

  • Moderate agonist Ki ~10-99nM

  • Weak agonist Ki ~100-999nM

  • Very weak agonist Ki ~1,000-up nM


(The reader is reminded that a smaller Ki is associated with the strongest effects.)

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.