Turmeric Cannabinoid Research

Turmeric Research Dashboard

7

Primary Studies

0

Related Studies

7

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

3

Animal studies

0

Laboratory studies

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CannaKeys has 7 studies associated with Turmeric.

Here is a small sampling of Turmeric studies by title:


Components of the Turmeric Research Dashboard

  • Top medical conditions associated with Turmeric
  • Proven effects in clinical trials for Turmeric
  • Receptors associated with Turmeric
  • Individual study details for Turmeric

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Overview - Turmeric

Description of Turmeric

Turmeric is a beautiful, flowering, yellow spice plant belonging to the ginger family (Zingiberacear). Its rhizome (root), often in the form of dried powder, is an essential ingredient for many types of Asian cuisine, especially Indian curries that found their origin in Ayurvedic medicine, whose practitioners used them as a vehicle for individualized medicine.

Curcumin modulates a long and complex list of molecular targets such as transcriptional factors, growth factor and growth factor receptors, protein kinases, inflammatory cytokines, enymes, apoptosis-related proteins, and others.

While turmeric does not bind with either of the classical endocannbinoid CB1 or CB2 receptor sites it has been demonstrated that curcumin was able to influence the expression of cannabinoid receptor sites (i.e., CB1 and CB2) and thus induce a sustained and dose-dependent modulation of endocannabinoid signaling, which in turn may be utilized to induce a number of clinically relevant effects.

Other Names:

Turmeric
Curcuma longa, Curcuma domestica, Curcuma aromatica, Curcumin, Curcumin syn.: Diferuloylmethane

IUPAC Name of Curcumin: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Molecular Formula of Curcumin: C21H20O6

Source–PubChem

Turmeric Properties and Effects

Curcumin:
• Enhances expression of CB1 receptor sites
• Improves mood such as depression (via improving monoaminergic signaling)
• Improved cognitive function in seniors
• Reduces inflammation (e.g., ↓inflammatory cytokines such as TNFα, NF-κβ, IL-1β)
• Mitigates excitotoxicity (e.g., by inhibiting glutamate)
• Neuroprotective agent (e.g., via stimulating neurotrophic factors such as BDNF)
• Reduces hypothalamic–pituitary–adrenal disturbances
• Improves insulin sensitivity
• Mitigates oxidative and nitrosative stress
• Enhances mitochondrial energy production
• ↓ Telomerase (a potential protective mechanism against cancer)

Turmeric Receptor Binding

Endocannabinoid System (ECS)
• ↑CB1 expression

Endocannabinoidome (eCBome)
• ↑PPAR-γ
• Serotonin (5-HT1A/1B)
• Dopamine (D1, D2)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.