Mast Cell Activation Syndrome – Cannabis Research

Mast Cell Activation Syndrome Research Dashboard


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CannaKeys has 5 studies associated with Mast Cell Activation Syndrome.

Here is a small sampling of Mast Cell Activation Syndrome studies by title:

Components of the Mast Cell Activation Syndrome Research Dashboard

  • Dosing information available for Mast Cell Activation Syndrome
  • Chemotype guidance for treating Mast Cell Activation Syndrome with cannabis
  • Synopsis of cannabis research for Mast Cell Activation Syndrome
  • Individual study details for Mast Cell Activation Syndrome

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Overview - Mast Cell Activation Syndrome

Description of Mast Cell Activation Syndrome

In MCAD the body’s own mast cells (mastocyte), which under normal conditions are responsible for the release of an array of inflammatory mediators that are part and parcel of natural inflammatory responses with its hallmark symptoms of redness, heat, pain and swelling. More specifically, at the cellular level these mediators include various inflammatory cytokines, oxidants, enzymes, histamines (anti-allergic compound), heparin (a naturally occurring anticoagulant), or neurotransmitters (i.e. serotonin) for example. When an excessive amount of chemical mediators are released severe vasodilation can induce anaphylaxis, a potentially life threatening allergic reaction, which if not treated immediately can lead to anaphylactic shock and subsequent death.

Disease Classification

Condition: Mast Cell Activation Syndrome
Disease Family:
Organ System: Immune System
ICD-10 Chapter: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
ICD-10 Code: D89

Mast Cell Activation Syndrome Symptoms:

Symptoms may come and go, and can include hives, pruritis, red or pale skin, swelling (mucus membranes e.g. eyes, mouth, throat), hot sensation, rapid heart rate, hypotention, dizzyness, shortness of breath, syncopy, anaphylaxis, anaphylactic shock, coma.

Also known as:

Mast Cell Activation Disorder, MCAD, MCAS, Idiopathic Mast Cell Activation Syndrome

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.