Macular Degeneration Research Dashboard
Double-blind human trials
Clinical human trials
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 7 studies associated with Macular Degeneration.
Here is a small sampling of Macular Degeneration studies by title:
- PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis
- CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
- Neuroprotective effects of the cannabinoid agonist HU210 on retinal degeneration
- Presence And Regulation Of Cannabinoid Receptors In Human Retinal Pigment Epithelial Cells
- Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.
Components of the Macular Degeneration Research Dashboard
- Dosing information available for Macular Degeneration
- Chemotype guidance for treating Macular Degeneration with cannabis
- Synopsis of cannabis research for Macular Degeneration
- Individual study details for Macular Degeneration
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Members can filter by the following criteria:
- Study Type
- Cannabinoids & Endocannabinoids
- Study Result
- Year of Publication
Overview - Macular Degeneration
Description of Macular Degeneration
Most common in seniors, macular degeneration is due to damage of the retina (the tissue lining the inner surface of the eye). It exists in wet or dry forms. Orthodox medicine has no cure and does not know the exact mechanism causing the disease's development. Possible causes include aging, family history, plaque build-up, high glycemic index food consumption, high blood pressure, smoking, and damage from oxidative stress.
Diseases of the Eye, Adnexa
ICD-10 Code: H35.3
Macular Degeneration Symptoms:
Distorted vision (e.g. blurred, lack of contrast, or blank spots in field of vision)
Also known as:
AMRD, Degeneration of the Macula and Posterior Pole
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.