Irritable Bowel Syndrome – Cannabis THC : CBD Ratios

Irritable Bowel Syndrome Research Dashboard

7

Primary Studies

40

Related Studies

47

Total Studies

Clinical Studies

3

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 47 studies associated with Irritable Bowel Syndrome.

Here is a small sampling of Irritable Bowel Syndrome studies by title:


Components of the Irritable Bowel Syndrome Research Dashboard

  • Dosing information available for Irritable Bowel Syndrome
  • Chemotype guidance for treating Irritable Bowel Syndrome with cannabis
  • Synopsis of cannabis research for Irritable Bowel Syndrome
  • Individual study details for Irritable Bowel Syndrome

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Overview - Irritable Bowel Syndrome

Description of Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a chronic and non-inflammatory syndrome (not a clearly defined condition) of the large intestines of mostly idiopathic origins that is defined by a group of symptoms. Orthodox medicine struggles to understand the precise causes of IBS and, to date, offers no cure. It is posited that IBS may be caused by stressful life events (mind-bowel axis) and as such it has a significant psychosomatic component to it (common co-morbidities include fibromyalgia, depression, anxiety, or chronic fatigue syndrome). IBS is typically classified according to the primary symptoms displayed by each patient. Thus diarrhea, constipation, and alternating diarrhea with constipation and infection become the basis for diagnosing the disease as IBS-D, IBS-C, IBS-A, or post-infectious IBS-PI, respectively.

Disease Classification

Condition: Irritable Bowel Syndrome
Disease Family: Gastrointestinal Disorder
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K58

Irritable Bowel Syndrome Symptoms:

Abdominal pain (e.g. bloating, cramping), abdominal distention, diarrhea, constipation, or both (alternating), imbalances in microbiome, common co-morbidities may include fibromyalgia, depression, anxiety, or chronic fatigue syndrome

Also known as:

IBS, Irritable colon, Spastic colon

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.