Foot Nail Fungus Research Dashboard
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CannaKeys has 2 studies associated with Foot Nail Fungus.
Here is a small sampling of Foot Nail Fungus studies by title:
- Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.
Components of the Foot Nail Fungus Research Dashboard
- Dosing information available for Foot Nail Fungus
- Chemotype guidance for treating Foot Nail Fungus with cannabis
- Synopsis of cannabis research for Foot Nail Fungus
- Individual study details for Foot Nail Fungus
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Overview - Foot Nail Fungus
Description of Foot Nail Fungus
The vast majority (90%) of foot nail fungal infections, or onychomycosis, are caused by fungi called dermatophytes that thrive in the keratin-rich environment of the outer layer of the skin, nails, or hair. Less commonly, onychomycosis can also occur in the fingernails and may be caused by yeasts and saprophytic mold.
Keratin is an evolutionarily significant protein that builds structural strength and provides toughness and protection superior to normal skin epithelium. It protects skin cells (epithelial cells) from stressors. However, once a vulnerability in the skin barrier exists, fungi may enter through cuts or cracks, where they settle and multiply. Fungi waste begins to cause irritation and erode the strength and toughness of the nail and the surrounding tissues.
Onychomycosis infections are widespread, and it is estimated that 1 in 10 people have it. Oral drugs are defined as clinically effective but still carry high failure and recurrence rates. They can also cause severe adverse effects with limited success.
Topical treatments have worse success rates and can take up to a year or more for some progress to show. Surgical debridement and laser treatments also have limited success rates. All of the above methods have high relapse rates.
Onychomycosis is not a fatal condition, but providers should be aware it may seldom lead to complications such as:
- Cellulitis
- Sepsis
- Osteomyelitis
- Surrounding tissue damage
- Nail loss
Disease Classification
Condition: Foot Nail FungusDisease Family: Infectious Disease (Fungus)
Organ System: Integumentary System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B35.1
Foot Nail Fungus Symptoms:
Brittle, discolored nails, inflamed skin around or below nail bed, loss of partial or whole nail, localized pain, foul odorAlso known as:
Onychomycosis , OM, Tinea UnguiumDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
