Foot Nail Fungus – Cannabis Research

Foot Nail Fungus Research Dashboard


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CannaKeys has 2 studies associated with Foot Nail Fungus.

Here is a small sampling of Foot Nail Fungus studies by title:

Components of the Foot Nail Fungus Research Dashboard

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  • Chemotype guidance for treating Foot Nail Fungus with cannabis
  • Synopsis of cannabis research for Foot Nail Fungus
  • Individual study details for Foot Nail Fungus

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Overview - Foot Nail Fungus

Description of Foot Nail Fungus

The vast majority (80-90%) of foot nail fungal infections, or onychomycosis, are caused by a fungi called dermatophytes that thrives in the keratin rich environment of the outer layer of the skin, nails, or hair. Keratin is a protein that builds structural strength and provides toughness. It protects skin cells (epithelial cells) from stressors. However, once vulnerability exists fungi may enter through cuts or cracks where it settles and multiplies. Fungi waste begin to cause irritation and erode the strength and toughness of the nail and the surrounding tissues. Onychomycosis infections are widespread, and it is estimated that 1 in 10 of all people have it. While oral drugs are defined as clinically effective, they can cause severe adverse effects and have limited success rates. Topical treatments have worse success rates and can take up to a year(s) for some progress to show. Surgical debridement and laser treatments also have limited success rates. All of the above methods have high relapse rates.

Disease Classification

Condition: Foot Nail Fungus
Disease Family: Infectious Disease (Fungus)
Organ System: Integumentary System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B35.1

Foot Nail Fungus Symptoms:

Brittle, discolored nails, inflammed skin around or below nail bed, loss of partial or whole nail, localized pain, bad odor

Also known as:

Onychomycosis , OM, Tinea Unguium

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.