Dupuytren’s Contracture – Cannabis THC : CBD Ratios

Dupuytren's Contracture Research Dashboard

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CannaKeys has 2 studies associated with Dupuytren's Contracture.

Here is a small sampling of Dupuytren's Contracture studies by title:


Components of the Dupuytren's Contracture Research Dashboard

  • Dosing information available for Dupuytren's Contracture
  • Chemotype guidance for treating Dupuytren's Contracture with cannabis
  • Synopsis of cannabis research for Dupuytren's Contracture
  • Individual study details for Dupuytren's Contracture

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Overview - Dupuytren's Contracture

Description of Dupuytren's Contracture

Dupuytren's Contracture (DC) is a connective tissue disorder that affects the palm. The disease primarily affects males from Northern European ancestry. Historical records date the condition back as far as the Vikings. Signs of DC begin very slowly and over a period of years, causing a thick build-up of hard and scar-like tissues surrounding the tendons of the palm. As a result the fingers (mostly the little and ring fingers) closest to the affected tendons begin to contract, leaving the hand in permanent misconfiguration or claw-like posture. The condition may be painless in some and painful in others, but all DC patients experience disability from the disfigured and immobile fingers. DC is a chronic degenerative condition whose causes are poorly understood. Modern medicine has no cure and treatment is limited to pharmaceuticals, surgery, or radiation. Drugs such as collagen preparations are injected directly into the affected tissue. Topical surgeries can range from breaking up the scar-like tissue using a needle (aponeurotomy) to complete amputation of the contracted fingers. Also used, especially in their earlier stages, are radiation therapies using ionizing radiation or electron irradiation. Each treatment is costly and can produce mild to serious adverse effects.

Disease Classification

Condition: Dupuytren's Contracture
Disease Family: Connective Tissue Disorder
Organ System: Muscular System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M72.0

Dupuytren's Contracture Symptoms:

Thickening of palmar fascia (esp. flexor tendons,most commonly affecting little or ring finger), reduced range of motion, frozen digits, frozen claw-like appearance, with or without pain

Also known as:

DC, Palmar Fascial Fibromatosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.