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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Bone Fractures studies by title:
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Bone fractures are generally classified as closed or open (compound) fractures. The latter are fractures where bone segments protrude through the surrounding tissue. Bone fractures may also be further categorized according to the pattern, shape, cause, or body part affected.
Closed fractures can range in severity from mild hairline fractures to partial or complete fractures, but where the surrounding tissue is still intact. A compound fracture is easy to spot. Bone is sticking out through the skin. There is severe pain, and localized swelling and bleeding are present.
Complete but closed fracture presents with dangling limbs, severe pain, and swelling without external blood loss. A closed but incomplete or partial fracture may only present with pain and swelling like a sprain or strain but most likely with increased intensities. Rarely, compartment syndrome may develop after a severe fracture.
In the orthodox medical paradigm, a minor fracture, such as a hairline fracture, is immobilized and treated with pharmaceutical medication to reduce inflammation and pain. This is also known as a closed reduction.
A completely fractured bone or unstable fracture is set (realigned) manually or surgically if necessary, and then placed into a semi-permanent cast for a period of 3 to 10 weeks (depending on the location of the fracture and age of the patient); the idea being that the fracture must remain undisturbed to heal. This is usually termed open (surgical) reduction and occurs commonly with internal fixation (e.g., ORIF) utilizing plates, screws, wires, and intermediary nails.
The healing of bone fractures involves several factors. Local factors include fracture characteristics, as well as infection and blood supply. Systemic factors that cause poor healing include advanced age, obesity, anemia, endocrine dysfunction, steroid medications, malnutrition, and smoking. The interprofessional team can employ dietary supplements (e.g., calcium, protein, vitamins C and D), bone stimulators, or even bone grafts to promote fracture healing.
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.