Amyotrophic Lateral Sclerosis (ALS) – Cannabis THC : CBD Ratios

Amyotrophic Lateral Sclerosis (ALS) Research Dashboard

12

Primary Studies

3

Related Studies

15

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

5

Animal studies

1

Laboratory studies

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CannaKeys has 15 studies associated with Amyotrophic Lateral Sclerosis (ALS).

Here is a small sampling of Amyotrophic Lateral Sclerosis (ALS) studies by title:


Components of the Amyotrophic Lateral Sclerosis (ALS) Research Dashboard

  • Dosing information available for Amyotrophic Lateral Sclerosis (ALS)
  • Chemotype guidance for treating Amyotrophic Lateral Sclerosis (ALS) with cannabis
  • Synopsis of cannabis research for Amyotrophic Lateral Sclerosis (ALS)
  • Individual study details for Amyotrophic Lateral Sclerosis (ALS)

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Overview - Amyotrophic Lateral Sclerosis (ALS)

Description of Amyotrophic Lateral Sclerosis (ALS)

ALS or Lou Gehrig's disease is considered a chronic degenerative neurological illness associated with the selective loss of only those nerve cells needed for muscular motion located in the brain and spinal cord. A-myo-trophic, derived from ancient Greek, translates into no-muscle-nourishment, respectively. 'Lateral' refers to muscles on either side of the affected nerve, and 'sclerosis' means hardening. Without nourishment, a muscle wastes away and with it so does the ability to initiate movements.

Disease Classification

Condition: Lou Gehrig's Disease
Disease Family: Neurological Disease
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G12.21

Amyotrophic Lateral Sclerosis (ALS) Symptoms:

Weakness, ataxia, shaky extremities, muscle spasms/cramps, expressive aphasia, difficulty swallowing, loss of bladder and bowel control, neuropathic pain, in some cases cognitive (e.g. dysfunction) and emotional changes (e.g. apathy, impulsive expressions)

Also known as:

Lou Gehrig's Disease, Motor Neuron Disease, Amyotrophic Lateral Sclerosis (ALS)

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.