Uveitis Research Dashboard
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CannaKeys has 7 studies associated with Uveitis.
Here is a small sampling of Uveitis studies by title:
- Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
- Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye
- Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity.
- Turning Down the Thermostat: Modulating the Endocannabinoid System in Ocular Inflammation and Pain
- The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation.
Components of the Uveitis Research Dashboard
- Dosing information available for Uveitis
- Chemotype guidance for treating Uveitis with cannabis
- Synopsis of cannabis research for Uveitis
- Individual study details for Uveitis
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Overview - Uveitis
Description of Uveitis
This disease is an inflammation of the uvea (the middle layer of the eye). Uveitis is primarily defined by which side of the uvea is affected. Anterior uveitis (aka iritis) refers to the inflammation being on the outermost side, while posterior uveitis (aka choroiditis) describes the affected inside layer. When both sides of the uvea are inflamed it is called pan-uveitis. No matter which form the illness takes, inflammatory cells can enter the gelatinous- like center of the eye and spread. In most case scenarios the infection occurs suddenly and spreads quickly. Uveitis can affect one or both eyes and depending on cause can be infectious or non-infectious.Disease Classification
Condition: UveitisDisease Family: Inflammatory Eye Disease
Organ System: Immune System, Nervous System
ICD-10 Chapter: Diseases of the Eye, Adnexa
ICD-10 Code: H44.13
Uveitis Symptoms:
Pain (e.g. burning), redness of sclera, blurred vision, photophobiaAlso known as:
Sympathetic UveitisDrug Interactions
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
- THC low dose: 0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
- THC medium dose: 6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
- THC high dose: 21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
(sample conversion calculated on a person weighing 75kg)
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
- CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
- CBD high dose: 100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
- (upper limits tested ~1,500mg)
(sample conversion calculated on a person weighing 75kg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.