Tinnitus – Cannabis THC : CBD Ratios

Tinnitus Research Dashboard

4

Primary Studies

2

Related Studies

6

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

3

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 6 studies associated with Tinnitus.

Here is a small sampling of Tinnitus studies by title:


Components of the Tinnitus Research Dashboard

  • Dosing information available for Tinnitus
  • Chemotype guidance for treating Tinnitus with cannabis
  • Synopsis of cannabis research for Tinnitus
  • Individual study details for Tinnitus

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Overview - Tinnitus

Description of Tinnitus

Tinnitus is defined by the auditory experience of sounds that others can’t hear. It is often described as a high-pitched sound reminiscent of hissing or ringing, and the sound experience may be subtle or significant. It may involve a one-sided experience or a bilateral one it can be constant or intermittent. Subjective tinnitus indicates an experience only the patient can hear while objective tinnitus refers to an auditory experience that can be heard by the examining physician by using a stethoscope for example. Depending on the person with tinnitus is can be a mild annoyance or a severe disability causing additional problems such as a lack of concentration or depression for instance. Causes include earwax, trauma or disease of the ear, other conditions such as MS, or psychological stress for example.

Disease Classification

Condition: Tinnitus
Disease Family: Diseases of the Ear and Mastoid Process
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Ear and Mastoid Process
ICD-10 Code: H93.1

Tinnitus Symptoms:

The experience of a noise or a sound without external stimulation of the auditory pathways. Intermittent sounds or chronic ones. The experience can vary greatly: some people experience hearing their own pulse, other a consistent high-pitched humming, while other may hear a loud, roaring sound. Additional symptoms may include a sense of irritation, frustration, insomnia, rumination, anxiety, or depression for instance.

Also known as:

Aurium Tinnitus, Tinnitus Aurium, Subjective Tinnitus, Objective Tinnitus, Persistent Tinnitus, Non-auditory Tinnitus, Non-vibratory Tinnitus, Pseudo Tinnitus, Vibratory Tinnitus, Pulsatile Tinnitus, Auditory Phantom Perception, Ringing in Ears

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.