Tic Disorders and Tourette Syndrome – Cannabis THC : CBD Ratios

Tic Disorders and Tourette Syndrome Research Dashboard

18

Primary Studies

9

Related Studies

27

Total Studies

Clinical Studies

5

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

11

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 27 studies associated with Tic Disorders and Tourette Syndrome.

Here is a small sampling of Tic Disorders and Tourette Syndrome studies by title:


Components of the Tic Disorders and Tourette Syndrome Research Dashboard

  • Dosing information available for Tic Disorders and Tourette Syndrome
  • Chemotype guidance for treating Tic Disorders and Tourette Syndrome with cannabis
  • Synopsis of cannabis research for Tic Disorders and Tourette Syndrome
  • Individual study details for Tic Disorders and Tourette Syndrome

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Overview - Tic Disorders and Tourette Syndrome

Description of Tic Disorders and Tourette Syndrome

Gilles de la Tourette Syndrome (GTS), more commonly referred to as Tourette syndrome (TS), is considered a developmental (most likely inherited) neurological and psychiatric disorder characterized by the presence of chronic motor and phonic tics. Tics (uncontrollable, repetitive, and non-rhythmic movements of select muscle groups including those needed to speak) provoke involuntary sounds, phrases, taboo words, or oddly appearing jerking motions such as slapping or grimacing. Tics range from being a minor inconvenience to completely debilitating.

Disease Classification

Condition: Tics and Tourettes
Disease Family: Seizure Disorder
Organ System: Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F95

Tic Disorders and Tourette Syndrome Symptoms:

Motor tics (e.g. eye twitching), verbal tics (e.g. sudden outbursts)

Also known as:

TS, Transient tic disorder, Tourette's disorder

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.