Tetanus – Cannabis THC : CBD Ratios

Tetanus Research Dashboard

6

Primary Studies

3

Related Studies

9

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 9 studies associated with Tetanus.

Here is a small sampling of Tetanus studies by title:


Components of the Tetanus Research Dashboard

  • Dosing information available for Tetanus
  • Chemotype guidance for treating Tetanus with cannabis
  • Synopsis of cannabis research for Tetanus
  • Individual study details for Tetanus

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Overview - Tetanus

Description of Tetanus

Tetanus is an acute and potentially fatal disease. The culprit is a potent protein toxin (i.e., tetanospasmin) produced by the bacteria Clostridium tetani. Tetanus occurs after a deep laceration or a puncture wound for instance. The disease exists in two forms: localized (typically milder) and generalized tetanus. Typically, localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form. The risk of tetanus can be reduced by tetanus vaccination. Before vaccines and modern treatments (e.g. tetanus immunoglobulin, antibiotics, antispasmodics) including as needed intensive care unit-related interventions tetanus was a dreaded condition that claimed untold victims. Earlier physicians were rendered helpless in its wake. Still, globally, (2019) 35,000 people (most of them children) succumbed to the illness
(Source: https://ourworldindata.org/tetanus).

Disease Classification

Condition: Lock-jaw, lockjaw
Disease Family:
Organ System: Immune System
ICD-10 Chapter: Certain infectious and parasitic diseases
ICD-10 Code: A35

Tetanus Symptoms:

Onset of signs and symptoms may occur within a few days to weeks later after infection and may include: fever, diaphoresis (sweating), difficulty swallowing, increase in heart rate and blood pressure, headaches, tetanic muscular contractions, tetanic muscular contractions near the site of injury in cases of localized tetanus, hyperreflexia, jaw spasms (lock-jaw aka trismus, rictus grin), opisthotonos (full body bridging position), spasms can progress to other and all parts of the body in cases of generalized tetanus, spasms can be very painful, it can lead to It can lead to lock-jaw making it impossible to open your mouth or swallow, in some cases the spasm can cause dislocation, fractures, and muscle tears.

Also known as:

Tetanic spasms, tetanic convulsions

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.