Temporomandibular Disorders – Cannabis THC : CBD Ratios

Temporomandibular Disorders Research Dashboard

7

Primary Studies

0

Related Studies

7

Total Studies

Clinical Studies

1

Clinical Meta-analyses

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

5

Animal studies

0

Laboratory studies

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CannaKeys has 7 studies associated with Temporomandibular Disorders.

Here is a small sampling of Temporomandibular Disorders studies by title:


Components of the Temporomandibular Disorders Research Dashboard

  • Dosing information available for Temporomandibular Disorders
  • Chemotype guidance for treating Temporomandibular Disorders with cannabis
  • Synopsis of cannabis research for Temporomandibular Disorders
  • Individual study details for Temporomandibular Disorders

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Overview - Temporomandibular Disorders

Description of Temporomandibular Disorders

The temporomandibular joint (TMJ) connects the mandible (jaw bone) to the skull. While often the specific causes for Temporomandibular disorders (TMD) are complex and considered ideopathic one common cause is attributed to damage or misalignment between the small shock-absorbing disc that buffers impact and balances motion between bone and cartilage. Contributing factors may include trauma, psychosocial factors (e.g. anxiety, stress, PTSD, depression), chronic degenerative diseases such as forms of arthritis, tissue disorders or genetic predisposition.

Disease Classification

Condition: TMJ, TMJ-disorder, TMD
Disease Family:
Organ System: Muscular System
ICD-10 Chapter: Diseases of the musculoskeletal system and connective tissue
ICD-10 Code: M26.6

Temporomandibular Disorders Symptoms:

Pain in jaw, pain in muscles surrounding temporomandibular joint (the joint that connects the jaw to the skull), pain can radiate to ears and face, joint lock sensation (may reduce capacity to open mouth), pain when chewing, the presence of clicking or grading sounds when moving the mandible, clenching of teeth, grinding of teeth

Also known as:

Arthralgia, bruxism (jaw pain associated with the grinding of the teeth), myalgia, local myalgia, myofascial pain, bilateral temporomandibular joint disorder, bilateral tmj disorder, temporomandibular joint disorder, disorder of bilateral temporomandibular joints, disorder of the left temporomandibular joint, disorder of the right temporomandibular joint, right temporomandibular joint disorder, light temporomandibular joint disorder, orofacial pain

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.