Systemic Sclerosis/Scleroderma – Cannabis THC : CBD Ratios

Systemic Sclerosis/Scleroderma Research Dashboard

10

Primary Studies

5

Related Studies

15

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

7

Animal studies

2

Laboratory studies

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CannaKeys has 15 studies associated with Systemic Sclerosis/Scleroderma.

Here is a small sampling of Systemic Sclerosis/Scleroderma studies by title:


Components of the Systemic Sclerosis/Scleroderma Research Dashboard

  • Dosing information available for Systemic Sclerosis/Scleroderma
  • Chemotype guidance for treating Systemic Sclerosis/Scleroderma with cannabis
  • Synopsis of cannabis research for Systemic Sclerosis/Scleroderma
  • Individual study details for Systemic Sclerosis/Scleroderma

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Overview - Systemic Sclerosis/Scleroderma

Description of Systemic Sclerosis/Scleroderma

The word sclero- in sclerosis or scleroderma is derived from the Greek word for hard and -derma for skin. If it only affects the skin it is referred to as scleroderma, when it effects other organs as well it is called systemic sclerosis. As you may have inferred symptoms include the hardening or thickening of connective tissue that surrounds the organs (e.g. lungs, heart, gastrointestinal organs, kidneys, or musculoskeletal system) due to an over production of collagen. The orthodox medical system does not know its precise causes but it is hypothesized to be an auto-immune disorder. Symptoms may include tough, tight, and hard skin, discolorations and/or tight facial tone. No allopathic cure is available. Managing treatments include topical and systemic pharmaceuticals.

Disease Classification

Condition: Systemic Sclerosis
Disease Family: Immune Disorder (connective tissue)
Organ System: Cardiovascular System, Digestive System, Immune System, Integumentary System, Muscular System, Urinary System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M34

Systemic Sclerosis/Scleroderma Symptoms:

Hardened skin, itching, joint pain, may involve certain organs: lung symptoms (pulmonary hypertension), gut symptoms (e.g. microbiome imbalance, GERD, decreased motility), kidney symptoms (e.g. renal failure)

Also known as:

SSC, Scleroderma

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.