Spinal Cord Injuries – Cannabis THC : CBD Ratios

Spinal Cord Injuries Research Dashboard

26

Primary Studies

3

Related Studies

29

Total Studies

Clinical Studies

6

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

8

Meta-analyses/Reviews

10

Animal studies

0

Laboratory studies

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CannaKeys has 29 studies associated with Spinal Cord Injuries.

Here is a small sampling of Spinal Cord Injuries studies by title:


Components of the Spinal Cord Injuries Research Dashboard

  • Dosing information available for Spinal Cord Injuries
  • Chemotype guidance for treating Spinal Cord Injuries with cannabis
  • Synopsis of cannabis research for Spinal Cord Injuries
  • Individual study details for Spinal Cord Injuries

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Overview - Spinal Cord Injuries

Description of Spinal Cord Injuries

An injury to the spinal column most commonly results from external trauma (car crash, gunshot, etc.) but may also result from internal trauma (stroke, aneurysm) or via certain diseases (cancer). The location of damage in the spinal cord determines the degree of disability. For example, a paraplegic person is paralyzed from the waist down after sustained damage to the thoracic or lower spine. A quadriplegic person paralyzed from the neck down loses the ability to move his arms or legs after sustaining damage to the spinal cord in the neck or brain itself.

Disease Classification

Condition: Spinal Cord Injuries
Disease Family: Trauma
Organ System: Skeletal System
ICD-10 Chapter: Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: S14

Spinal Cord Injuries Symptoms:

Depending on location of affected vertebrae (paraplegia, quadriplegia) symptom include: Loss of movement (flaccidity), loss of sensation (e.g. numbness, tingling, itching), loss of bowel and/or bladder control, muscle spasms, central pain (pain in spinal cord), difficulty clearing mucus from throat or lungs

Also known as:

SCI, Injury of brachial plexus, Concussion and edema of cervical spinal cord

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.