Severe Stress Reaction/Oxidative Stress – Cannabis THC : CBD Ratios

Severe Stress Reaction/Oxidative Stress Research Dashboard

41

Primary Studies

32

Related Studies

73

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

21

Animal studies

14

Laboratory studies

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CannaKeys has 73 studies associated with Severe Stress Reaction/Oxidative Stress.

Here is a small sampling of Severe Stress Reaction/Oxidative Stress studies by title:


Components of the Severe Stress Reaction/Oxidative Stress Research Dashboard

  • Dosing information available for Severe Stress Reaction/Oxidative Stress
  • Chemotype guidance for treating Severe Stress Reaction/Oxidative Stress with cannabis
  • Synopsis of cannabis research for Severe Stress Reaction/Oxidative Stress
  • Individual study details for Severe Stress Reaction/Oxidative Stress

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Overview - Severe Stress Reaction/Oxidative Stress

Description of Severe Stress Reaction/Oxidative Stress

Reactive oxygen species (ROS) are molecules that contain the element oxygen (e.g. hydrogen peroxide, superoxide) which are very biologically reactive. The human body utilizes ROS as an efficient means to rid the body of harmful invaders such as toxins, bacteria or viruses. This process is initiated by a number of immune cells (e.g. white blood cells) which engulf the pathogen and douse them with the oxidant. In a balanced and healthy body ROS safely perform their immune function and destroy the pathogen without harming adjacent cells of the body itself. In fact, healthy human cells are protected by naturally occurring enzymes that break down ROS into harmless parts of water and oxygen (microbes lack these enzymes). And, while the oxidation of pathogens or toxins is a natural immune response an excess or chronic exposure to ROS (e.g. aging) can overwhelm this naturally oxidant vs anti-oxidant balancing mechanism and induce oxidative stress severe enough to damage healthy cells and as such can pose a significant threat to health and well being.

Disease Classification

Condition: Oxidative Stress
Disease Family: Deprivation Disorder
Organ System: Cardiovascular System, Digestive System, Endocrine System, Immune System, Integumentary System, Mental/Emotional System, Muscular System, Nervous System, Reproductive System, Respiratory System, Skeletal System, Urinary System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F43.0

Severe Stress Reaction/Oxidative Stress Symptoms:

Reduced resillience (increased susceptibility to develop disease), slower wound healing (pro-inflammatory state), increased concentration of free radical (e.g. oxidative stress), impaired cognitive/affective function (e.g. poor memory, stress eating), progression to mood disorders (e.g. anxiety, PTSD)

Also known as:

Acute crisis reaction, Acute stress disorder, Acute situational disturbance

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.