Schizophrenia – Cannabis THC : CBD Ratios

Schizophrenia Research Dashboard

34

Primary Studies

38

Related Studies

72

Total Studies

Clinical Studies

4

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

20

Meta-analyses/Reviews

6

Animal studies

1

Laboratory studies

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CannaKeys has 72 studies associated with Schizophrenia.

Here is a small sampling of Schizophrenia studies by title:


Components of the Schizophrenia Research Dashboard

  • Dosing information available for Schizophrenia
  • Chemotype guidance for treating Schizophrenia with cannabis
  • Synopsis of cannabis research for Schizophrenia
  • Individual study details for Schizophrenia

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Overview - Schizophrenia

Description of Schizophrenia

Schizophrenia remains one of the most common and serious yet least understood mental illnesses in the world today. Swiss psychiatrist Eugene Bleuler first used the word "schizophrenia" in 1911, which he derived from the Greek words schizo (to split) and phren (brain or mind). However, unlike common usage suggests, it does not necessarily refer to a split personality(-ies) but rather a split or disconnect between thinking and feeling. The allopathic tradition considers this type of mental illness a chronic condition that requires lifelong treatment. In this paradigm, no cure exists and treatment consists of managing symptoms, employing antipsychotic pharmaceutical drugs with psychological or social support.

Disease Classification

Condition: Schizophrenia
Disease Family: Mental-Emotional Disorder
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F20

Schizophrenia Symptoms:

Hallucinations, cognitive dysfunction (e.g. misinterpreting, miscommunicating, poor memory), missmatching sensory perceptions (e.g. thought/feeling, beliefs/behavior), paranoia, poor social interaction, chronic negative affect

Also known as:

SCHz

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.