Renal Failure – Cannabis THC : CBD Ratios

Renal Failure Research Dashboard

2

Primary Studies

8

Related Studies

10

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 10 studies associated with Renal Failure.

Here is a small sampling of Renal Failure studies by title:


Components of the Renal Failure Research Dashboard

  • Dosing information available for Renal Failure
  • Chemotype guidance for treating Renal Failure with cannabis
  • Synopsis of cannabis research for Renal Failure
  • Individual study details for Renal Failure

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Overview - Renal Failure

Description of Renal Failure

There are two basic types, one is due to acute causes (i.e. acute kidney failure) with a typically rapid onset, while the other is characterized as chronic kidney disease which tends to develop over longer periods of time. Acute versions can be triggered by extreme dehydration, trauma (e.g. large surface area burns, blood loss), reduced renal blood supply (e.g. blood clots), pharmaceutical drugs (e.g. ace inhibitors), allopathic medical procedures (e.g. dyes employed during imaging tests), or blocked renal pathways (e.g. tumor) for instance. Causes for chronic kidney disease-based failures include events such as hypertension, exposure to toxins (e.g. heavy metals, alcohol), kidney disease (e.g. cancer, polycystic kidney disease), obstructions (e.g. stones, enlarged prostrate), and one of the most frequent causes diabetes (type I & II) for example. Shared underlying pathologies may include obstruction along the line of urinary pathways from the kidney through the ureters, bladder, or urethra; damage to the kidneys themselves; or from inadequate blood supplies to the kidneys.

Disease Classification

Condition: Kidney Failure
Disease Family: Kidney Disorder
Organ System: Urinary System
ICD-10 Chapter: Diseases of the Genitourinary System
ICD-10 Code: N17

Renal Failure Symptoms:

Symptoms may be similar in nature for both types when kidney function is beginning to be more significantly impaired and as such may include: flank pain, hematuria (bloody urine), reduced urine output, fatigue, fluid retention (swollen ankles), nausea/vomiting, altered mental status, shortness of breath.

Also known as:

SA-AKI, Acute Kidney Failure

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.