Psychosis – Cannabis THC : CBD Ratios

Psychosis Research Dashboard

44

Primary Studies

21

Related Studies

65

Total Studies

Clinical Studies

3

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

36

Meta-analyses/Reviews

3

Animal studies

1

Laboratory studies

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CannaKeys has 65 studies associated with Psychosis.

Here is a small sampling of Psychosis studies by title:


Components of the Psychosis Research Dashboard

  • Dosing information available for Psychosis
  • Chemotype guidance for treating Psychosis with cannabis
  • Synopsis of cannabis research for Psychosis
  • Individual study details for Psychosis

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Overview - Psychosis

Description of Psychosis

Psychosis is a mental-emotional disorder defined by the inability or difficulty to discern what is real or not. While precise causation is subject to on-going speculation a considerable number of possible causes include pharmaceutical medications (e.g. benzodiazepines), recreational drugs (e.g. alcohol abuse, speed), specific illnesses (e.g. Alzheimer's disease, syphilis) specific mental conditions (e.g. schizophrenia), the experience of physical (e.g. PTSD) and psychosocial trauma (significant life changes such as moving rural to an urban area) for example. Contributing factors may include the experience of giving birth, chronic stress, disruption of dopamine signaling (e.g. Parkinson's disease). Orthodox medicine does not have a cure and current treatments are limited to pharmaceutical anti-psychotic medication, psychological and social support.

Disease Classification

Condition: Psychosis
Disease Family: Mental-Emotional Disorder
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F29

Psychosis Symptoms:

Illusions, hallucinations, mismatch between the senses (e.g. auditory visual delay), difficulty function in world, atypical behavior, incoherent speech, socially withdrawn, sleep disturbances, chronic negative affect

Also known as:

Unspecified schizophrenia spectrum

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.