Poisoning by Synthetic Cannabis – Cannabis THC : CBD Ratios

Poisoning by Synthetic Cannabis Research Dashboard

24

Primary Studies

0

Related Studies

24

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

22

Meta-analyses/Reviews

1

Animal studies

1

Laboratory studies

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CannaKeys has 24 studies associated with Poisoning by Synthetic Cannabis.

Here is a small sampling of Poisoning by Synthetic Cannabis studies by title:


Components of the Poisoning by Synthetic Cannabis Research Dashboard

  • Dosing information available for Poisoning by Synthetic Cannabis
  • Chemotype guidance for treating Poisoning by Synthetic Cannabis with cannabis
  • Synopsis of cannabis research for Poisoning by Synthetic Cannabis
  • Individual study details for Poisoning by Synthetic Cannabis

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Overview - Poisoning by Synthetic Cannabis

Description of Poisoning by Synthetic Cannabis

Synthetic cannabinoids are man-made molecules that interact with the endocannabinoid system in ways significantly more potent and potentially more dangerous that their distant plant-based cousins or the body's own versions of them. Overdoses are relatively common and can lead to severe adverse effects and deaths. Sold under the a great variety of street names such as "Spice," "Bonsai" or "K2" their chemical building blocks are often readily available for purchase on the internet. A recent meta-analyses from Australia (2019) describes AB-CHMINACA as being the most commonly seen synthetic cannabinoid in the accidental deaths of cases reported on the continent down under.

Disease Classification

Condition: Synthetic Cannabis Issues
Disease Family: Toxic Exposure
Organ System: Nervous System
ICD-10 Chapter: Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T40.4

Poisoning by Synthetic Cannabis Symptoms:

Confusion, paranoia, panic attacks, hallucinations, aphasia, ataxia, nausea/vomiting, seizure activity, organ failure, coma, death

Also known as:

Synthetic Cannabis Use Disorder

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.