Migraine – Cannabis THC : CBD Ratios

Migraine Research Dashboard

19

Primary Studies

3

Related Studies

22

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

16

Meta-analyses/Reviews

2

Animal studies

1

Laboratory studies

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CannaKeys has 22 studies associated with Migraine.

Here is a small sampling of Migraine studies by title:


Components of the Migraine Research Dashboard

  • Dosing information available for Migraine
  • Chemotype guidance for treating Migraine with cannabis
  • Synopsis of cannabis research for Migraine
  • Individual study details for Migraine

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Overview - Migraine

Description of Migraine

Migraines are recurring headaches that range from moderate to severe. Severe migraines lasting for hours or days can be debilitating to the point where all you want to do is draw the curtains and curl up into the fetal position. One patient described it this way: "The pulse of my own heartbeat becomes a drum of pain pounding against the walls of my skull with no end in sight." The pain can induce nausea and vomiting. Other symptoms often include severe sensitivity to light and sounds. A number of people see paranormal flashes of light (called auras) signaling the migraine's arrival, while other early indications (prodromes) might consist of a craving for chocolate, aversion to noise, or sudden mood shifts to depression, anxiety, or elation. Within the allopathic tradition, the precise causes and cure for migraines remain unknown but one of the leading physical culprits under consideration include abnormalities in blood vessels of the scalp or brain. While scientists also hypothesize that hormonal change, stressors, weather changes, and food sources may play roles as triggers in migraine attacks, evidence remains inconclusive. Management of triggers through individual observations, diaries, consequent implementation of trigger avoidance, and prophylaxis through supportive lifestyle choices such as nutrition and exercise has given back some sense of control to many patients. Treatment consists of numerous oral and injectable pharmaceuticals. Depending on underlying physiology, sometimes blood vessel surgery provides relief.

Disease Classification

Condition: Migraine
Disease Family: Neurological Condition
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G43

Migraine Symptoms:

Severe pain, stiff neck, rapid mood swings, prodrome, aura, nausea/vomiting, photophobia (hypersensitivity to light), extremely sensitive to sounds and smells

Also known as:

Hemiplegic migraine, Chronic Migraine, Ophthalmoplegic migraine, Cyclical vomiting, Abdominal Migraine, Cluster headache

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.