Liver and Intrahepatic Bile Duct Cancer – Cannabis THC : CBD Ratios

Liver and Intrahepatic Bile Duct Cancer Research Dashboard

15

Primary Studies

4

Related Studies

19

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

3

Animal studies

12

Laboratory studies

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CannaKeys has 19 studies associated with Liver and Intrahepatic Bile Duct Cancer.

Here is a small sampling of Liver and Intrahepatic Bile Duct Cancer studies by title:


Components of the Liver and Intrahepatic Bile Duct Cancer Research Dashboard

  • Dosing information available for Liver and Intrahepatic Bile Duct Cancer
  • Chemotype guidance for treating Liver and Intrahepatic Bile Duct Cancer with cannabis
  • Synopsis of cannabis research for Liver and Intrahepatic Bile Duct Cancer
  • Individual study details for Liver and Intrahepatic Bile Duct Cancer

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Overview - Liver and Intrahepatic Bile Duct Cancer

Description of Liver and Intrahepatic Bile Duct Cancer

Hepatocellular carcinoma (HCC) is the third leading cause of cancer- related death worldwide. While numerous types of liver cancers exist, HCC is by far the most common form. The allopathic community cannot pinpoint the exact cause of liver cancer. Statistically significant risk factors in the development of liver cancer may include gender (the disease is more common in males), history of chronic hepatitis B or C, cirrhosis, fatty liver, diabetes, toxins, alcoholism, L-carnitine deficiencies, or obesity. Traditional treatment consists of chemotherapy, radiation, surgery (tumor removal or transplant), cold applications (cryoprobe), heat (radiofrequency ablation), and injections of pure alcohol into the tumor sites.

Disease Classification

Condition: Liver Cancer
Disease Family: Cancer
Organ System: Digestive System
ICD-10 Chapter: Neoplasms
ICD-10 Code: C22

Liver and Intrahepatic Bile Duct Cancer Symptoms:

Jaundice, abdomnial discomfort or pain, dark urine, itchy skin, loss of appetite, unexpected weight loss, nausea/vomiting, intolerance to fatty food, light colored stool

Also known as:

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.